Ceramide signalling in oxidized phospholipid (oxPL)-induced RAW 267.4 macrophage cell deathvoriconazoletacrolimusinteractiondosing schemehematopoietic SCTtherapeutic drug monitoringConcomitant use of tacrolimus and voriconazole, both competitive inhibitors of the CYP450 3A4 isoenzyme, requires tacrolimus dose ...
PL-125 Reduced cardiovascular risk in obese patients after bariatric surgery is related to ceramide-mediated reduction in APO B level and (ApoB)/ (ApoA-I) ratioBackground Obesity-associated hyperlipidemia and hyperlipoproteinemia are risk factors for cardiovascular disease (CVD). Recently, sphingo...
The progressive accumulation of glycosphingolipids, most notably globotriaosylceramide (GL-3), leads to renal, cardiovascular, and other clinical manifestations over decades. In a single-arm phase 2 study, glucosylceramide synthase inhibition with venglustat led to a reduction in lysosomal GL-3 ...
Effect of FB1 on OxPL induced CerS activation and ceramide levels.Lingaraju M. HalasiddappaHarald KoefelerAnthony H. FutermanAlbin Hermetter