PKM2-IN-3 | MedChemExpress 英文名称: 总访问: 71 国产/进口: 进口 半年访问: 12 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2025-2-13 货号: HY-139667 CAS 号: 2408841-19-8 参考报价: 电询 立即询价 电话咨询 ...
In vitro studies on the THP-1 cells were also performed. RESULTS :The DM-STEMI group had a higher value of peak TnI and a higher GRACE risk score than the non-DM-STEMI group (p<.05). The highest expression levels of PKM2, NLRP3, interleukin (IL)-1尾, and IL-18 and the lowest ...
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Therefore, the results suggest that DHA can induce pyroptosis of ESCC cells via the PKM2-caspase-8/3-GSDME pathway. Implication: In this study, we identified new mechanism of DHA in inhibiting ESCC development and progression, and provide a potential therapeutic agent for the treatment of ESCC....
PKM2NLRP3 inflammasomepyroptosisObjectives. Muscle cell necrosis is the most common pathological manifestation of idiopathic inflammatory myopathies. Evidence suggests that glycolysis might participate in it. However, the mechanism is unclear. This study aimed to determine the role of glycolysis in the ...
Western blot was used to assess the expression levels of PKM2, NLRP3, Caspase‐1, Cleaved Caspase‐1, GSDMD, GSDMDN, and IL‐1β. Results: The expression of PKM2 elevated in hippocampal tissues of the HIBD model and the localization of PKM2 in the hippocampus was activated in neurons ...
Concomitant expression of SMYD3 and PKM2 positively correlated with poor progression-free and overall survival in patients with DLBCL and may serve as novel biomarkers in DLBCL.doi:10.1038/s41419-022-05208-7Tian Tiangrid.452404.30000 0004 1808 0942Department of PathologyFudan University Shanghai ...
Coimmunoprecipitation assays showed lack of association between HIF-1α and PKM2 in NP cells. Results support the role of the PHD3 as a cofactor for HIF-1, independent of PKM2-JMJD5.-Schoepflin, Z. R., Silagi, E. S., Shapiro, I. M., Risbud, M. V. PHD3 is a transcriptional ...
Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.SALITURO Francesco G.SAUNDERS Jeffrey O....
2-Demethoxy-2,3-ethylenediamino hypocrellin B (EDAHB)A549 cellsPyruvate kinase M2 (PKM2)Proteome2-Demethoxy-2,3-ethylenediamino hypocrellin B (EDAHB) is an efficient photosensitizer that mediates cancer cell apoptosis. In order to better understand the molecular mechanisms involved in its anti...