Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the ...
It is now accepted that the PKM2 in the tetrameric state has an allosteric regulatory domain within its spatial structure, forming a pattern similar to the seesaw, when some allosteric regulators are inserted into the spatial structure involved in PKM2 allosteric regulation. After the domain (Fig....
Their pattern of expression and regulation might reflect the specific function and energetic requirements of the different tissues in which they are present. The four isoforms are encoded by two genes, PKLR and PKM2 (herein referred to as PKM), and their expression is regulated by tissue-specific...
PKM2, function and expression and regulation Cell Biosci., 9 (2019), p. 52 View PDFView articleCrossrefGoogle Scholar 8 J.C. Alves-Filho, E.M. Palsson-McDermott Pyruvate kinase M2: a potential target for regulating inflammation Front. Immunol., 7 (2016), p. 145 View in ScopusGoogle Sc...
PKM2, function and expression and regulation. Cell Biosci. 9, 52 (2019). Article PubMed PubMed Central Google Scholar Iqbal, M. A. et al. Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative ...
PKM2, function and expression and regulation [J]. Cell Biosci, 2019, 9: 52. [5] Zhu S, Guo Y, Zhang X, et al. Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics [J]. Cancer Lett, 2021, 503: 240-248. 中草药 2022 年 1 月第 53 卷第 2 期 Chinese Traditional and ...
regulation of gene expression and tumorigenesis. 来源:生物谷
In this review, we briefly introduce the function of PKM2 in tumorigenesis and its activity regulation. 中 Keywords PKM2; Warburg effect; tumor metabolism; tumorigenesis; regulation of enzyme activity 近年来, 代谢调控逐渐成为肿瘤发生发展机制 “ ” [1] 为 有氧糖酵解 , 具体的机制至今仍未阐明 。
最近报道了与促炎基因iNOS 表达减少和组织修复基因 ARG1 表达增加相关的巨噬细胞表型的时间依赖性变化(Metabolic regulation of gene expression by histone lactylation. Nature. 2019)。 研究表明,巨噬细胞可以从促炎表型转变为修复表型。 最近的研究表明,抑制糖酵解或乳酸可以刺激巨噬细胞的这种转变 (The glycolysis...
PKM2, function and expression and regulation Cell Biosci., 9 (2019), p. 52 View PDFView articleCrossrefGoogle Scholar [10] K. Zahra, T. Dey, S.P. Ashish, U. Mishra, Pandey Pyruvate kinase M2 and cancer: the role of PKM2 in promoting tumorigenesis Front Oncol., 10 (2020), p. 159...