2024年5月,东北师范大学的相关研究人员在《EMBO Journal》(IF:11.4)上发表了题为“PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer”的研究论文,揭示了丙酮酸激酶M2(PKM2)作为组氨酸激酶的新功能,并促进PGAM1活性在癌细胞代谢重编程过程中促进糖酵解分流和大...
2024年5月,东北师范大学的相关研究人员在《EMBO Journal》(IF:11.4)上发表了题为“PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer”的研究论文,揭示了丙酮酸激酶M2(PKM2)作为组氨酸激酶的新功能,并促进PGAM1活性在癌细胞代谢重编程过程中促进糖酵解分流和大...
通过GEPIA网站(http://gepia.cancer-pku.cn/)对TCGA数据库中33种肿瘤(表1)患者肿瘤组织和正常组织PKM2的mRNA水平进行分析,并分析该基因的表达水平与癌症患者预后的总体生存率的关系。 表1TCGA数据库中肿瘤中英文名称及缩写Table 1The name and abbreviation of tumor in ...
2024 年 1 月 24 日,江南大学附属医院肿瘤研究所黄朝晖课题组关于糖代谢关键基因丙酮酸激酶 M2 型(PKM2)可变剪切的新成果LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alte...
The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in cancer. In addition, some studies have shown that the upregulation of PKM2 in tumor tissues is associated with the altered expression of lncRNAs and the poor survival. Therefore,...
此外,核内乙酰化的PKM2部分参与了PSAT1介导的细胞迁移过程。 参考文献: [1] Rumeysa B, et al. Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells[J]. Cancers, 2021....
Pyruvate kinase M2 (PKM2), a subtype of pyruvate kinase (PK), has been shown to play an important role in the development of cancer. It regulates the last step of glycolytic pathway. PKM2 has both pyruvate kinase and protein kinase activity, and the conversion of these two functions of PKM...
2021年9月6日,威斯康星大学麦迪逊分校医学院许伟教授团队在 EMBO J 上发表题为PKM2-TMEM33 axis regulates lipidhomeostasisin cancer cells by controlling SCAP stability的研究成果。该研究发现,PKM2 可以通过下游分子TMEM33和RNF5调节SCAP稳定性,进而激活SREBPs通路。
[4]Tumor-associated macrophages induce PD-L1 expression in gastric cancer cells through IL-6 and TNF-ɑsignaling[J].Xiaoli Ju;;Heng Zhang;;Zidi Zhou;;Miao Chen;;Qiang Wang.Experimental Cell Research,2020 [5]张程鹏.SIRT1调控PKM2去乙酰化抑制蛋白稳定性的机制及其在胃癌代谢重编程中的作用[D].南方...
关键词 :有氧糖酵解(Warburg效应);PKM2;肿瘤发生 中图分类号:R 730 文献标志码:A Role of pyruvate kinase M2 in tumor metabolism and development SUN Qian (Dept.of Immunology,Key Laboratory of Cancer Prevention and Therapy,Tianjin Cancer Institute and Hospital Tianji n Medical University,Tianjin ...