Results: After stimulation with TGF-beta we can demonstrate an enhanced and prolonged activation of PI3K/AKT and ERK1/2 in PKC alpha-knockout (PKC alpha-/-) podocytes compared to PKC alpha-wildtype (PKC alpha+/+) podocytes, whereas proapoptotic signaling via p38MAPK is significantly reduced....
(protein kinase C alpha) is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a...
Knockout of PKC alpha enhances insulin signaling through PI3K Mol. Endocrinol., 16 (2002), pp. 847-858 Google Scholar 138 F. Oriente, F. Andreozzi, C. Romano, G. Perruolo, A. Perfetti, F. Fiory, et al. Protein kinase C-α regulates insulin action and degradation by interacting with...
Protein kinase C-alpha (PKCα) was recently reported to increase myocardial stiffness, an effect that was proposed to be due to phosphorylation of two highly conserved sites (S11878 and S12022) within the proline-glutamic acid-valine-lysine (PEVK) rich spring element of titin. To test this...
We transfected organotypic hippocampal slices from wildtype (WT) or PKCα knockout (KO) mice with small GTPase sensors and imaged CA1 pyramidal neurons using 2pFLIM. In response to glutamate uncaging targeted to a single dendritic spine (30 pulses at 0.5 Hz), the stimulated spine from...
Proteintech's Mouse Monoclonal PKC Alpha antibody is validated in IF/ICC and shows reactivity with human, mouse, rat samples.
kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling ...
many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]...
Anti-PKC Alpha/PRKCA (Phospho-T638) Antibody (Clone#OTI3D2)产品规格:50μl|100μl|150μl发货周期:1~3天产品价格:询价本产品仅可用于科研实验,严禁用于其他非科研用途!抗体名称 Anti-PKC Alpha/PRKCA (Phospho-T638) Antibody (Clone#OTI3D2) 指标别名 AAG6;PKC A;PKC alpha;PKCA;PKCα;PRKACA;...
The PKC-mediated increase in ENaC activity was associated with an increase in blood pressure in knockout mice fed a high-salt diet. 展开 关键词: Kidney Tubules, Collecting Animals Protein Kinase C-alpha Epithelial Sodium Channels DOI: 10.1152/ajprenal.00678.2013 年份: 2014 ...