Moreover, the intracellular Ca2+ chelator BAPTA-AM decreased the phosphorylation of p38 MAPK and CREB but failed to reduce PKA activation. In summary, p38 MAPK/CREB activation via PKA activation and increased cellular Ca2+ helped to alleviate Mn-induced neuronal apoptosis via BDNF regulation. These...
和p38MAPK-ATF2信号通路 方法 1.分别用2.0,10.0,20.0肛mol/LAOH作用NIH3T3细胞1h,检测NIH3T3细 IR 郑州大学2009年博士学位论文 中文摘要 胞中PKA的活化水平;作用2h,检测CREB的活化水平。20.0/zmol/L AOH作 用细胞0,30,60和120min,检测NIH3T3细胞中PKA和CREB的活化水平。
As one of the targets of PKA, CREB promotes cancer cell proliferation, survival and migration, and negatively associates with cancer patients survival [136]. cAMP also induces CREB3L1 expression through PKA-p38MAPK pathway [137]. While CREB3L1 promotes the growth and metastasis of anaplastic thyr...
The MKK3-p38 MAPK pathway has been reported to mediate larval settlement in Amphibalanus (=Balanus) amphitrite. To clarify the underlying molecular mechanism, we applied label-free proteomics to analyze changes in the proteome of cyprids treated with a p38 MAPK inhibitor. The results showed that th...
» Protein Interactions » Fc gamma receptor SPR binding assays » Kinascreen SPR services » EGFR / ERBB1 / HER1 » ERBB4 / HER4 » FGF-R1 » LYN » c-MET » p38 MAPK » PKA » PKB / AKT » Drug Development ...
裂原活化蛋白激酶(MAPK)信号转导通路的激活。为了探索免疫调变过程中其他信号对MAPK通路的影响,以 LPS调变小鼠腹腔抑制性巨噬细胞为模型,研究了cAMP/PKA和佛波酯(PMA)/PKC信号对MAPK家族成员 p44/p42(胞外调控激酶1/2,extracellularregulatedkinase1/2,ERK1/2)、c2JunN端激酶(JNK)和p38的调节作用。
Fasudil诱导肌动蛋白应力纤维的紊乱及细胞迁移的抑制[4],抑制肝星状细胞的扩散、应力纤维的形成以及α-SMA的表达,同时伴有细胞生长的抑制,但不诱导细胞凋亡。Fasudil抑制LPA诱导的ERK1/2、JNK和p38 MAPK的磷酸化[5]。 体内活性 Fasudil (30 μg) 通过犬只冠状动脉内注射,可使脑血流量(CBF)约增加50%。Fasudil(...
研究了小鼠腹腔抑制性巨噬细胞cAMP/PKA 和PMA/PKC信号对致分裂原澈活蛋白激酶 MAPK p44/p42 (ERK1/2),JNK和p38 MAPK的调节.结果表明:1).LPS诱导了小鼠腹腔巨噬细胞cAM... 林明群,张宗粱 - 中国细胞生物学学会会议 被引量: 15发表: 0年 蛋白激酶A(PKA)介导的信号通路:正调节还是负调节? 蛋白激酶A是...
Xie et al. revealed that PS-MPs exposure activated the p38 MAPK signaling pathway and induced oxidative stress in mouse testes, resulting in reproductive toxicity in mice [29]. Fatemeh Amereh et al. indicated that the concentrations of testosterone, LH and FSH in the serum of male rats ...
For example, in the fission yeast Schizosaccharomyces pombe, the 2-Cys Prdx, Tpx1, is important for H2O2-induced activation of the p38-related Sty1 mitogen-activated protein kinase (MAPK), with which it forms intermolecular disulfide complexes [45]. Indeed, disulfide complexes have now been det...