cAMP遵循一条独特的路线,并激活一个单一的PKA-AKAP复合物接近底物,以介导一个独特的生物效应。因此,每个底物似乎都有自己的固定PKA池和自己的局部cAMP梯度。PKA通过抑制14-3-3蛋白与BAD(通过14-3-3/BAD signaling)和NFAT的相互作用,促进细胞存活。PKA通过限制其在红血球...
cAMP遵循一条独特的路线,并激活一个单一的PKA-AKAP复合物接近底物,以介导一个独特的生物效应。因此,每个底物似乎都有自己的固定PKA池和自己的局部cAMP梯度。PKA通过抑制14-3-3蛋白与BAD(通过14-3-3/BAD Signaling)和NFAT的相互作用,促进细胞存活。PKA通过限制其在红血球中谱蛋白-肌动蛋白网络组装过程中的作用来,...
Feng等发现直接增强细胞内 cAMP活性的药物(8- Br-cAMP和霍乱毒素)均能下调体外培养的小鼠腹膜巨噬细胞内毒素刺激后 IL-12的 mRNA转录, 抑制 IL-12的分泌, 而且该效应不依赖于 PKA活化, 可能与抑制丝裂原活化蛋白激酶(mitogen-activatedproteinkinase, MAPK)p38 的活...
As one of the targets of PKA, CREB promotes cancer cell proliferation, survival and migration, and negatively associates with cancer patients survival [136]. cAMP also induces CREB3L1 expression through PKA-p38MAPK pathway [137]. While CREB3L1 promotes the growth and metastasis of anaplastic thyr...
In addition, beauvericin suppressed cAMP-PKA-CREB signaling and upregulated expression of LXR-伪, resulting in the suppression of p38 MAPK. Our results indicate that beauvericin attenuates melanogenesis by regulating both cAMP/PKA/CREB and LXR-伪/p38 MAPK pathways, consequently leading to a reduction...
P450arom和雌激素生成的诱导作用.此外,PKA的 催化亚基还可通过激活p38MAPK及磷脂酰肌醇3 激酶(PI3K),从而激活相应的信号转导通路促进颗 粒细胞的增殖分化. 4.p38/MAPK途径FSH通过cAMPPKA途 径激活p38/MAPK通路,调节细胞形态,提高细胞存 活率,促进细胞分化.Maizels等…】发现,FSH依赖 PKA可迅速激活p38/MAPK.p38...
For example, in the fission yeast Schizosaccharomyces pombe, the 2-Cys Prdx, Tpx1, is important for H2O2-induced activation of the p38-related Sty1 mitogen-activated protein kinase (MAPK), with which it forms intermolecular disulfide complexes [45]. Indeed, disulfide complexes have now been det...
This more robust pattern of stimulation causes the catalytic subunit of PKA to recruit p42 MAPK and both then move to the nucleus where they phosphorylate transcription factors and activate gene expression required for the induction of long-term memory[48, 49]. In addition to protein kinases, ...
p38 MAPK-mediated transcriptional activation of inducible nitric oxide synthase in glial cells: Roles of nuclear factors, NFκB, CREB, C/EBP and ATF2 p38 MAPK-mediated transcriptional activation of inducible nitric oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, c...
Xie et al. revealed that PS-MPs exposure activated the p38 MAPK signaling pathway and induced oxidative stress in mouse testes, resulting in reproductive toxicity in mice [29]. Fatemeh Amereh et al. indicated that the concentrations of testosterone, LH and FSH in the serum of male rats ...