4. Clark.D.E.(2003).In silico prediction of bood-brain barrier permeation.Drug Discovery Tday.8.927-933. 5. Roda,A.,et al.(1996).Synthesis andphysicochemical, biological,and pharmacological properties of new bile acids amidated with cyclic amino acids.Journal of Medicinal Chemisry, 39.2270-...
The dissociation constant (pKa) of non – polar amino acids including (alanine, glycine, valine phenylalanine and tryptophan) were determined by potentiometric titration technique. The pKa values obtained by extrapolation for alanine, glycine, and valine were 10.29, 9.87 and 9.91 respectively. The ...
5. Roda,A.,et al.(1996).Synthesis andphysicochemical, biological,and pharmacological properties of new bile acids amidated with cyclic amino acids.Journal of Medicinal Chemisry, 39.2270-2276.6. Chen,P.,et al.(2004).ImidazoquinoxalineSre-family kinase p56LCK inhibitors: SAR,QSAR,and the discov...
PKA Inhibitor Fragment (6-22) amide is a PKA inhibitor peptide composed of 17 amino acids in a straight chain. In cellular biology, protein kinase A (PKA) is a family of enzymes whose activity depends on the cyclic AMP (cAMP) at the cellular level. PKA is also considered a cAMP depende...
Amino Acids12Special Nitrogen Compounds28 Peptides13Hydroxylamines28 Nitrogen Compounds14Hydrazines28 Aliphatic amines15, 17, 19Semicarbazones28 Cyanoamines16Amidoximes28 Anilines17, 18, 20Thiols29 Nucleosides21Carbon Acids30,31 Special Table Heterocycles22Indicators31 Acridine23References32-34 Benzo...
5. Roda,A.,et al.(1996).Synthesis and physicochemical, biological,and pharmacological properties of new bile acids amidated with cyclic amino acids.Journal of Medicinal Chemisry, 39.2270-2276. 6. Chen,P.,et al.(2004).Imidazoquinoxaline Sre-family kinase p56LCK inhibitors: SAR,QSAR,an...
5. Roda,A.,et al.(1996).Synthesis andphysicochemical, biological,and pharmacological properties of new bile acids amidated with cyclic amino acids.Journal of Medicinal Chemisry, 39.2270-2276. 6. Chen,P.,et al.(2004).ImidazoquinoxalineSre-family kinase p5...
pKa
Any of a group of kinases that phosphorylate the amino acids serine, threonine, and tyrosine in certain proteins, that regulate essential aspects of cell growth and movement, and that can cause cancer and other diseases when dysfunctional.
Yueju confers antidepressant effects in a rapid and long-lasting manner, similar to ketamine. CREB (cAMP-response element binding protein) signaling is implicated in depression pathology and antidepressant responses. However, the role of CREB and associa