The PKC inhibitors bisinolylmaleimide I ((2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide) and G-7874 {2[1[(3-Dimethylaminopropyl)-5-methozyindol-3-yl]-3-(1H-indol-3-yl) hydrochloride} completely reversed the tolerance to morphine in both the hot-plate ...
1H-INDOLE;Indol;1H-Indol;FEMA 2593;Benzazole;1-BENZAZOLE;Benzopyrrole;BENZO(B)PYRROLE;2,3-BENZOPYRROLE;1H-indole analogue 中文名: 吲哚 中文别名: 吲哚;氮茚;氮杂茚;熔吲哚;纯吲哚;鍚插摎;苯并吡咯;吲哚CP;吲哚 溶液;柯凡克试剂 CBNumber: ...
The 8-hr tolerance to the low-efficacy μ-agonist meperidine and the moderate-efficacy μ-agonists, morphine and fentanyl was fully reversed by the PKC inhibitors Bisindolymaleimide I, and Gö6976 as well as the PKA inhibitor PKI 14-22. However tolerance to DAMGO, a highly efficacious μ-...
When PKC inhibitors bisindolymaleimide IV (0.5 µM) and chelerythrine Cl (5.0 µM) were used in combination, a significant (p<0.001) reduction in relaxation (48.1±6.1 vs 23.8±4.1%) was observed. 2-APB (126µM) produced a significant (p<0.001) reduction in CCK-induced tension (...