The 8-hr tolerance to the low-efficacy μ-agonist meperidine and the moderate-efficacy μ-agonists, morphine and fentanyl was fully reversed by the PKC inhibitors Bisindolymaleimide I, and Gö6976 as well as the PKA inhibitor PKI 14-22. However tolerance to DAMGO, a highly efficacious μ-...
1H-INDOLE;Indol;1H-Indol;FEMA 2593;Benzazole;1-BENZAZOLE;Benzopyrrole;BENZO(B)PYRROLE;2,3-BENZOPYRROLE;1H-indole analogue 中文名: 吲哚 中文别名: 吲哚;氮茚;氮杂茚;熔吲哚;纯吲哚;鍚插摎;苯并吡咯;吲哚CP;吲哚 溶液;柯凡克试剂 CBNumber: ...
Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents New conazole antifungals, in the series of triazole alcohols 23a–d and 24a–e incorporating an indole moiety substituted at 5-position by halogens, a cyan....
When PKC inhibitors bisindolymaleimide IV (0.5 µM) and chelerythrine Cl (5.0 µM) were used in combination, a significant (p<0.001) reduction in relaxation (48.1±6.1 vs 23.8±4.1%) was observed. 2-APB (126µM) produced a significant (p<0.001) reduction in CCK-induced tension (...