Learn the definition of pKa in chemistry and take a look at how to use pKa to determine the strength of an acid.
QSAR,and the discovery of (S)-N-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinylimidazo-[1.5-alpyrido[3.2-e]pyrazin-6-amine(BMS-279700)as a potent and orally active inhibitor with excellent in vivo antinflammatory activity. Journal of Medicinal Chemistry,47, 4517-4529....
What is RSD in analytical chemistry? What is a weak acid? What is protease? What is the pH scale used for? What is EDTA titration? What is biological chemistry? What is a strong acid? What is a solvent in biology? What is DMS organic chemistry? What is the pH of lemon juice? What...
DebabrataChatterjee,Rudivan Eldik, inAdvances in Inorganic Chemistry, 2023 3.3.1Reduction of O2by [RuII(edta)(H2O]2− The [RuII(edta)(H2O)]2−complex is extremely oxygen sensitive. In presence of oxygen it undergoes one-electron oxidation to produce the [RuIII(edta)(H2O)]−complex. ...
The pKa in Organic Chemistry Let’s first define the meaning of a strong acid. According to the Arrhenius theory, acids dissociate in water to form protons (H+). The general equation for acid dissociation can be shown as: For a specific example, we can look at the dissociation of hydroc...
从这个角度看，定水为14，与所有热力学数据和实验结果都是匹配的，而且逻辑上也非常顺畅。搞一个15.7...
Sulfonamide structure-activity relation in a cell-freesystem. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters. Journal of Medicinal Chemistry, 15, 700-706. 4. Clark.D.E.(2003).In silico prediction of bood-brain barrier permeation.Drug Discovery...
inhibitors: SAR,QSAR,and the discovery of (S)-N-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinylimidazo-[1.5-alpyrido[3.2-e]pyrazin-6-amine(BMS-279700)as a potent and orally active inhibitor with excellent in vivo antinflammatory activity. Journal of Medicinal Chemistry,47, 4517-4529....
- 《Journal of Biological Chemistry》 被引量: 125发表: 2002年 Controlling chemoselectivity in vinyl and allylic C-X bond activation with palladium catalysis: a pK(a)-based electronic switch It has been demonstrated that the same Pd catalyst can be used to effect allylic substitution or vinylic...
Sulfonamide structure-activity relation in a cell-freesystem. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters. Journal of Medicinal Chemistry, 15, 700-706. 4. Clark.D.E.(2003).In silico prediction of bood...