PK/PD StudiesIdsa
该研究显示,对美罗培南敏感的致病菌(MIC≤2 mg/L),治疗重症HAP时采用常规方案(1g q8h iv 30 min)可获得PK/PD达标;对美罗培南MIC为4mg/L的病原体,增加剂量或延长至3h滴注(1g q8h iv 3h)可获得PK/PD达标;对美罗培南耐药致病菌(MIC=8 mg/L),...
给药方案为 750 mg,每日 1 次,从 PK/PD 角度看临床可以采用该剂量方案,但需考虑如下几点: 750 mg 尚未开展验证性临床研究,仅开展了探索性临床研究,纳入 59 例患者;健康人研究显示 750 mg 有潜在的 QTc 间期延长风险,此对病毒性肺炎患者可能同样适用;病毒性肺炎患者需有明确病原学诊断依据和体外药敏结果,支...
As PD studies in children are generally more complicated to perform than PK studies, this is where a big challenge in pediatric pharmacological research ... Elke,H,J,... - 《Expert Opinion on Drug Metabolism & Toxicology》 被引量: 10发表: 2015年 Targeting the TGF-β RI kinase with LY215...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook PANK2 (redirected fromPKAN) Acronyms PANK2 A gene on chromosome 20p13 that encodes a member of the pantothenate kinase family, which are key enzymes in coenzyme A (CoA) synthesis. PANK2 catalyses the first...
Choose rewarding Pharmacology, Toxicology, Pharmacodynamics, PK PD, Jobs, and Career as a Pharmacokinetics Sr. scientist at NorthEast BioLab.
We discuss different types of approximations of the individual Fisher information matrix used in population optimal design software tools and describe a Monte-Carlo option in the PkStaMp library which constructs optimal sampling schemes for population pharmacokinetic (PK) and pharmacodynamic (PD) studies....
不同PI策对美罗培南肺内PK/PD的影响 ■ 重症HAP患者肺局部PK/PD监测 重症患者体内药物代谢变化各异,临床医生常常有这样的体会,即便分离出同种病原体且对于同一种抗菌药物的MIC指标相同,随着感染部位的变化,治疗效果也存在差异。单纯使用循环中PK/PD作为药物评估指标的在很多情况下,可能具有误导性,并能实际反应局部...
NIH 2017R01 GM MALDI-MS Imaging of Cells Exposed to 3D-Printed Fluidic Devices for PK/PD StudiesHummon, Amanda B. / University of Notre Dame $266,844 NIH 2016R01 GM MALDI-MS Imaging of Cells Exposed to 3D-Printed Fluidic Devices for PK/PD StudiesHummon, Amanda B. / University of Notr...
PK/PD models in antibacterial development:Velkov, T. et al.; Curr Opin Microbiol . 2013, 16(5) [open access] Hollow-fiber pharmacodynamics studies and mathematical modeling to predict the efficacy of amoxicillin for anthrax postexposure prophylaxis in pregnant women and children.Louie, A et al....