The objective of this pharmacokinetic/pharmacodynamics (PK/PD) analysis was to characterize the PK and PD properties of LY3015014 and assess the effect of covariates on the LY3015014 PK-PD profiles. Methods Single and multiple dose data from three phase1 studies in healthy subjects ( n =133),...
BackgroundContinuous hemodiafiltration (CHDF) is used as renal replacement therapy for critically ill patients with renal failure, and to treat hypercytokinemia. Since CHDF also clears therapeutic agents, drug pharmacokinetics (PK) should be dependent upon CHDF conditions. Although the antibiotic biapene...
Key words: PK-PD model; pharmacokinetics; pharmacodynamics; drug concentration; safe medication 药物代谢动力学又称药动学(pharmacokinetic, PK),是一门借助动力学原理,用数学模型定量分 析药物在机体内吸收,分布,代谢和排泄(absorption, distribution, metabolism and excretion,ADME)量变 规律的学科.药物效应动力学...
The industry's most trusted PK/PD platform for non-compartmental analysis (NCA), population PK (popPK), IVIVC, and more. Find out more...
The relationship between late lumen loss and restenosis among various drug-eluting stents: A systematic review and meta-regression analysis of randomized c... Aims To relate late lumen loss (LLL) after drug-eluting stent (DES) implantation to angiographic (BAR) and target vessel revascularization ...
a中药有效组分的PK-PD相关分析对于揭示和确证中药组效关系具有重要意义。 The Chinese native medicine effective component PK-PD correlation analysis has the vital significance regarding the revelation and the proof Chinese native medicine group effect relations.[translate]...
Mutational analysis of select regions of BRAF, NRAS, and KRAS genes were also performed. Plasma drug concentrations were also determined at tumor tissue collection.In general, both Cand AUCof PD-0325901 increased proportionally with the doses tested. The time to peak plasma concentration occurred ...
为此,定量药理学专著《Introduction to Population Pharmacokinetic/Pharmcodynamic Analysis with Nonlinear Mixed Effects Models》(Joel S. Owen与Jill Fiedler-Kelly合著)的中文译本《PK/PD建模实践——NONMEM软件入门》正式出版发行。 中译本《P...
Through numerous examples and over 100 tutorials, scientists learn how to apply PK/PD analysis in a variety of practical areas, from simple plasma kinetics, multi-compartment models, nonlinear kinetics, plasma protein binding, pharmacodynamic models, turnover concepts, receptor binding, functional adapta...
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic ... Z Yong,M Huo,J Zhou,... - 《Comput...