Day, et al., “Post-Training N-Methyl-D-Aspartate Receptor Blockade Offers Protection from Retrograde Interference but does not Affect Consolidation of Weak or Strong Memory Traces in the Water Maze”, Neuroscience, 137:19-28 (2006). During, et al., “Controlled Release of Dopamine from a...
In like manner, the free base can be regenerated from the acid-addition salt form in the conventional manner, that is by treating the salts with cold, weak aqueous bases, for example alkali metal carbonates and alkali metal bicarbonates. The bases thus regenerated can then be interacted with ...
acetate such as sodium acetate. The reaction with the acid halide is preferably effected with the acyl bromide in the presence of a strong acid such as trifluoroacetic acid. The hydrobromide salts may be converted to the free base by action with a weak base such as an alkali metal ...
longer reaction times can be employed if desired. The excess diazomethane in the reaction mixture can be decomposed by the addition of a weak acid, for example acetic acid, or alternatively by evaporation. The product is isolated by removal of the reaction solvent, thereby providing a 1,2,3,...
Testing the in vitro antiviral activity against respiratory syncytial virus (RSV), compounds 76–78 showed moderate to weak effects. The IC50 (μM) values of 76–78 against RSV were 75.2 ± 1.1, 35.1 ± 0.6, and 10.1 ± 0.3, respectively, while the IC50 (μM) of ribavirin (the ...