In some cases, the addition of an acid-binding agent, for example of an alkali or alkaline earth metal hydroxide, carbonate or bicarbonate or of another salt of a weak acid of the alkali metals or alkaline earth metals, preferably of potassium, sodium or calcium, or the addition of an org...
"Pharmaceutically acceptable acid addition salts" are those salts formed by the compounds with any acid which is physiologically compatible in warm-blooded animals, such salts being formed by either strong or weak acids. Representative of strong acids are hydrochloric, hydrobromic, sulfuric and phosphori...
Testing the in vitro antiviral activity against respiratory syncytial virus (RSV), compounds 76–78 showed moderate to weak effects. The IC50 (μM) values of 76–78 against RSV were 75.2 ± 1.1, 35.1 ± 0.6, and 10.1 ± 0.3, respectively, while the IC50 (μM) of ribavirin (the ...
A weak harmonic restraint of 0.5 kcal·mol−1·Å−2 was initially imposed on the protein’s Cα atoms (except for those in the 187Asp-Ala193 stretch) to promote ligand, water and counterion equilibration. Trajectory snapshots were saved every 0.1 ns for further analysis. In addition, ...