Using the values obtained for the enthalpies of reaction, the acidity order of the salts is obtained: FeBr>MnBr and CoBr>NiBr. Comparing with pyridine adducts, the ligand piperidine is more basic than the ligand pyridine: pipd>py.doi:10.1007/s10973-012-2755-yP. Oliver Dunstan...
We have also unexpectedly found that DGAT inhibitors can be used to elevate the levels of one or more satiety hormones, in particular glucagon-like-peptide-1 (GLP-1) and therefore DGAT inhibitors, in particular DGAT1 inhibitors, can also be used to prevent or treat a disease which can benef...
solubilitymiscible in water and alcohol; soluble in ether, acetone, benzene and chloroform maximum allowable concentration: not established; more toxic, irritating and volatile than pyridine (Reinhardt and Brittelli 1981). pka11.123(at 25℃)
Of the synthetic copolymers mentioned, the ones which are more suited to stabilization according to the present invention, are the polyolefins deriving from monomers having the general formula: R--CH.dbd.CH.sub.2, wherein R is an alkyl or aryl group, or a hydrogen atom. Of the polyolefins,...
Furthermore, this compound exhibits potential biological activities, making it a subject of interest in the field of pharmacology. Overall, 3-Hydroxy-1-methylpiperidine is a versatile compound with significant applications in the chemical and pharmaceutical industries. View more+ ...
Show moreView chapterExplore book Thin-Layer Chromatography for Evaluation of Herbal Drugs Pulok K. Mukherjee, in Quality Control and Evaluation of Herbal Drugs, 2019 8.12.6.3.1 Alkaloids of Ornithine and Lysine Origin Pyrrolidine, pyrrolizidine, pyrazole, pyridine, piperidine and quinolizidine alkaloids...
The high basicity of amidines is due to the resonance stabilization of their protonated forms. Guanidines, on the other hand, which carry three nitrogen atoms in one amine and two imine moieties are even more basic [3,4]. Due to the importance of amidines, numerous synthetic routes for ...
Furthermore, in one compound, i.e., meso-transdiene (Compound 14), the nicotinic receptor interaction has been eliminated and the compound is relatively selective for inhibition of DAT. The 2,6-disubstituted piperidino and 2,6-disubstituted piperazino analogs of the present invention exhibited ...
3. The method of claim 1 wherein the compound administered is 2-{1-methyl-6-[2-(4-methylphenyl)-2-oxoethyl]-2-piperidinyl}-1-phenyl-1-ethanone hydriodide. Description:FIELD OF THE INVENTION The present invention relates to new substituted pyridine or piperidine compounds and to their use ...
The present invention is directed to pyridyl piperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and