and peak serum concentration is nine times higher in cats given the same mg/kg dosage as dogs.32Despite such findings, the dosage that is approved for dogs is routinely given to cats.29–31,fThe risk–benefit ratio of such an approach is unknown, either in the short term or long term....
Pimobendan has been studied for treating heart failure and cardiomyopathy, primarily for veterinary uses. Mechanism of action The mechanism of mild mitral regurgitation (MR) in dogs treated with Pimobendan is a dual mechanism of action, which enhances myocardial contractility by increasing calcium ...
One of the authors (Gordon) has been using pimobendan (0.25–0.3 mg/kg PO) in addition to background heart failure therapy for > 6 years in over 300 dogs for the treatment of CHF from both DCM and CVD. In one unpublished study from these 300 dogs, survival and hemodynamic effects we...