The cardiac pathology/histopathology noted in the 3X and 5X dose groups is typical of positive inotropic and vasodilator drug toxicity in normal dog hearts, and is associated with exaggerated hemodynamic responses to these drugs. None of the dogs developed signs of heart failure and there was no ...
A sound theoretical argument for digoxin can be made in dogs with heart failure, normal sinus rhythm, and maintained myocardial function only ifthe owners cannot afford pimobendan. However, discretion must be used in these dogs, as other drugs will control signs with less danger of toxicity....