别名 PFTalpha;Pifithrin-Alpha 英文名称 Pifithrin-α hydrobromide/PFTα CAS 63208-82-2 分子式 C16H18N2OS·HBr 分子量 367.3 纯度 ≥98% 单位 支 生物活性 Pifithrin-α hydrobromide是 p53 抑制剂,可阻断其转录活性并阻止细胞凋亡。Pifithrin-α能够阻断GOX诱导的Bcl-2蛋白减少。Pifithrin-α是一种有效的AhR...
Pifithrin-alpha-HBr是 p53 抑制剂。 特异性阻断肿瘤抑制因子 p53 转录活性，并可抑制热休克和糖皮质激素信号通路。 此外，Pifithrin-alpha-HBr 还可以保护细胞免受 p53 介导的细胞凋亡。 体内活性； 保护小鼠免受与 p53 诱导相关的化疗副作用。 也是aryl hydrocarbon receptor(AHR) 激动剂。图1.Pifithrin-α-HBr...
PFTalpha blocks p53-mediated induction of p21/Waf-1 in human embryonic kidney cells. PFTalpha does, however, cause a left shift in the dexamethasone dose response curve by increasing intracellular dexamethasone concentration. 体内研究:Pifithrin-α (2.2 mg/kg i.p.) treatment completely rescues ...
Pifithrin-alpha-HBr是 p53 抑制剂。 特异性阻断肿瘤抑制因子 p53 转录活性,并可抑制热休克和糖皮质激素信号通路。 此外,Pifithrin-alpha-HBr 还可以保护细胞免受 p53 介导的细胞凋亡。 体内活性; 保护小鼠免受与 p53 诱导相关的化疗副作用。 也是aryl hydrocarbon receptor(AHR) 激动剂。 图1.Pifithrin-α-HBr...
[5] Komarova EA, et al. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278: 15465–15468(2003). [6] Leker RR, et al. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin α. Exp Neurol,...
关键字 inhibit | Pifithrin-a (PFTa) HBr | Ferroptosis | Pifithrin α hydrobromide | Inhibitor | Aryl Hydrocarbon Receptor | MDM-2/p53 | Pifithrin-alpha | PFTa Hydrobromide | Pifithrin-alpha Hydrobromide | Pifithrin-a | AhR | Pifithrin | PFTalpha Hydrobromide | Pifithrin Hydrobromide | PFTalpha...
Pifithrin-alpha HBr价格, Pifithrin-alpha H...电议中国武汉VIP10年武汉天植生物技术有限公司2024-03-12询价 Pifithrin-α hydrobromide电议美国VIP1年MedChemExpress(MCE中国)2025-02-14询价 Pifithrin-α hydrobromide(Pifithrin hydrob...电议VIP4年上海芮晖化工科技有限公司2025-02-25询价 ...
英文别名 A) HBr | Pifithrin-a hydrobromide | La2(CO3)3 | 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone,hydrobromide | lithiumhydroxide-hydrate | pifithrin alpha | Pifithrin-alpha (PFTalpha) | Pifithrin-alpha hydrobromide | SY10941 规格或纯度 10mM ...
英文别名A) HBr | Pifithrin-a hydrobromide | La2(CO3)3 | 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone,hydrobromide | lithiumhydroxide-hydrate | pifithrin alpha | Pifithrin-alpha (PFTalpha) | Pifithrin-alpha hydrobromide | SY10941 ...
Treatment with pifithrin-alpha, a chemical p53 inhibitor, did not change apoptosis and autophagy levels but caused an increase in proliferation and migration of newborn cells to the granule cell layer of the dentate gyrus and to the hilus. However, a week after the last seizure, p53 ...