Thecoverpictureshowsfluorescenttaggingoftheepigeneticmodification5-hydroxymethylcytosine(5-hmC)alongadouble-strandedDNAmoleculeIntheirwork,YEbenstein,MFridman,andco-workersshowthat5-hmCsiteswithinmammaliangenomicDNAthatarefoundatCpGdinucleotidescanbedirectlylabeledinaone-potchemoenzymaticcascadeFirst,anenzymaticreaction...
beads (each contains only copies of the same DNA molecule) deposited on slide Pool of oligonuceotides of fixed length labeled according to sequenced ... SA Taylor,VL Friesen - 《Marine Ecology Progress》 被引量: 31发表: 2012年 Jamestown : the buried truth What was life really like for th...
DNA enzyme; DNA; fluorescence; limit of detection The cover picture shows the concept of self-assembling deoxyribozyme sensors for nucleic acid analysis. Two DNAzyme subunits and a fluorophore- and a quencher-labeled reporter substrate coexist free in solution. The addition of a nucleic acid analyt...
In the example above, a green dot would indicate that the gene was expressed more in healthy tissue, since the dominance of the green fluorescence indicates that the healthy sample mRNAs were more numerous than the unhealthy ones. A red dot indicates that the gene was producing more mRNAs in...
(18F), with radioactive half-lives of 20 and 110 min, respectively. Due to these short half-lives, PET radioligands are generated in a cyclotron and are rapidly incorporated into the molecule of interest immediately prior to their use (8). In SPECT, the commonly used isotope is technetium...
Cover Picture: Molecular Composition of Sub‐stoichiometrically Labeled α‐Synuclein Oligomers Determined by Single‐Molecule Photobleaching (Angew. Chem. Int. Ed. 35/2012)α‐SynucleinEinzelmoleküluntersuchungenPhotobleichenProteineZijlstra N, Blum C, Segers-Nolten IM, Claessens MM, Subramaniam V....