Murine monoclonal antibodies (MAbs) selective for an idiotope on a monoclonal antibody (IgG 1/kappa) to human myelin basic protein (MBP) peptide 80–89 were prepared by immunization with a synthetic decapeptide specified by RNA that is complementary to the mRNA for human MBP peptide 80–89. ...
Strain A/J mice immunized with azobenzenearsonate (ABA)-mouse IgG conjugates develop suppression for anti-trinitrophenyl(TNP) responses to doubly conjugate... Lewis,G. - 《Journal of Experimental Medicine》 被引量: 133发表: 1978年 Murine B cell leukemia (BCL1): organ distribution and kinetics...
We analyzed the structural correlates underlying the insulin-dependent selection of the specific anti-insulin IgG1 kappa mAb13-producing cell clone, derive... Y Ichiyoshi,M Zhou,P Casali - 《Journal of Immunology》 被引量: 80发表: 1995年 Isolation and characterisation of a human anti-idiotypi...
Co-crystallographic studies of human IgM RF-AN bound to IgG4 Fc showed that the Ab residues involved in autorecognition are all located at the edge of the conventional combining site surface, leaving much of the RF light chain CDRs (CDR-L1, -L2, and -L3) potentially available for ...
Using an autologous anti-A1 allotypic reagent, the major antigenic heterogeneity detected by swine, rabbit and goat anti-IgG2 reagents was due to their propensity to recognize the AI allotope. All heterologous reagents and most monoclonals so far test are biased in their specificity toward this ...
The class, subclass and light chain distribution of eight myeloma proteins with anti-streptolysin路activity (ASO) in sera studied by our group and in cases from the literature indicates a predominance of the IgG1 kappa subclass and type of immunoglobulins. Three IgG myeloma proteins (O.I., L....
These mAbs, Cyd-1 (IgG2b, kappa), Guo-1 (IgG1, kappa) and Guo-2 (IgG1, kappa) were derived from splenocytes of A/J mice immunized with Cyd-KLH or Guo-KLH and recognized the nucleoside base moieties involved in hydrogen bonding. The interactions between Guo-1 or Guo-2 and Cyd-...
In order to define this system more exactly we have now produced two murine monoclonal antibodies directed against bovine milk κ-casein to use as clonal tools to identify specific antiidiotypes in these human sera. Kappa-casein is an important part of the casein micelle in milk and cheese; ...
Idiotype vaccine against Hodgkin's lymphoma: generation and characterization of an anti-idiotypic monoclonal antibody against the Hodgkin-associated (anti-... The monoclonal -3 (Ab1; isotype IgG1-Kappa), that defines the antigen (m.w. 120,000) expressed by Hodgkin-Reed Sternberg was used to ...