monoclonal antibodies directed against certain domains of Factor VIII have been isolated by some research teams. Thus, a human monoclonal antibody of the IgG4kappa type, LE2E9, has been isolated. This antibody is directed against the C1 domain of Factor VIII and inhibits the cofactor activity of...
We have produced 199 murine monoclonal ant... RA Miller,S Hart,M Samoszuk,... - 《New England Journal of Medicine》 被引量: 134发表: 1989年 Platelet-reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia Autoimmune ...
These mAbs, Cyd-1 (IgG2b, kappa), Guo-1 (IgG1, kappa) and Guo-2 (IgG1, kappa) were derived from splenocytes of A/J mice immunized with Cyd-KLH or Guo-KLH and recognized the nucleoside base moieties involved in hydrogen bonding. The interactions between Guo-1 or Guo-2 and Cyd-...
We analyzed the structural correlates underlying the insulin-dependent selection of the specific anti-insulin IgG1 kappa mAb13-producing cell clone, derive... Y Ichiyoshi,M Zhou,P Casali - 《Journal of Immunology》 被引量: 80发表: 1995年 Mimotope and Anti–Idiotypic Vaccines to Induce an Ant...
All heterologous reagents and most monoclonals so far test are biased in their specificity toward this determinant. A second type of serological heterogeneity, recognized by only certain heterologous reagents, was their specificity for what we have called the IgG2b isotype of IgG2. This isotype is...
Co-crystallographic studies of human IgM RF-AN bound to IgG4 Fc showed that the Ab residues involved in autorecognition are all located at the edge of the conventional combining site surface, leaving much of the RF light chain CDRs (CDR-L1, -L2, and -L3) potentially available for ...