该基因编码的蛋白属于磷酸肌醇3激酶(PI3K)家族pi3激酶在参与细胞增殖、癌基因转化、细胞存活、细胞迁移和细胞内蛋白质转运的信号传导途径中发挥作用。该蛋白包含一个脂质激酶催化结构域和一个C末端C2结构域,这是II类PI3激酶的特征C2结构域作为钙依赖性磷脂结合基序,介导蛋白质向膜的转运,也可能介导蛋白质-蛋白质的相...
To further explore these functional consequences in human disease, I have identified two compounds that have the potential to inhibit the kinase activity of PI3K-C2alpha as high nM inhibitors. Overall, this dissertation summarizes my work on how PI3K-C2alpha links endocytosis and autophagy....
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Mechanism involved in the regulation of the novel class II phosphoinositide 3-kinase (PI3K-C2 alpha) by protein kinase cKtori, CShepherd, P R
Class II phosphoinositide 3-kinases (PI3K-C2) are large multidomain enzymes that control cellular functions ranging from membrane dynamics to cell signaling via synthesis of 3′-phosphorylated phosphoinositides. Activity of the alpha isoform (PI3K-C2α) is associated with endocytosis, angiogenesis, and...
Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module. Molecular Cell. doi:10.1016/j.molcel.2018.06.042 . 71:343-351.e4.Wang, H.; Lo, W.T.; Vujicˇic´ Zagar, A.; Gulluni, F.; Lehmann, M.; Scapozza, L.; Haucke, V.; Vadas, O. ...
规格 Accession Number:NP_002636.1 Form:Frozen Kinase Group:Lipid Kinases Protein Form:Catalytic Research Category:Drug Development Shipping Condition:Dry Ice Species:Human Molecular Weight:171.1 kDa Gene Alias:PIK3C2A (PI3K-C2 alpha) Validated Application:Kinase Assay ...
Nevertheless, mTORC2 or Akt inhibition does not alter PI3K beta-dependent platelet spreading on fibrinogen. The activation of the small GTPase Rap1b downstream of integrin alpha IIb beta 3 is regulated by PI3K beta but is not affected upon inhibition of either mTORC2 or Akt. Altogether, these...