简述了 PI3K/Akt/mTOR/p70 S6K 信号通路作用于肝星状细胞(HSC)而对肝纤维化发生发展产生的作用,分析表明阻断该信号通路中任一靶点均能抑制 HSC 活化、增殖,促进 HSC 凋亡,抑制 HSC 分泌细胞外基质和延缓肝纤维化进程,阻断该通路有望成为肝纤维化的治疗策略。关键词:肝硬化;1 - 磷脂酰肌醇 3 - 激酶;蛋白...
et al. Modified Linggui Zhugan Decoction (加味苓桂术甘汤) Ameliorates Glycolipid Metabolism and Inflammation via PI3K-Akt/mTOR-S6K1/AMPK-PGC-1 α Signaling Pathways in Obese Type 2 Diabetic Rats. Chin. J. Integr. Med. 28, 52–59 (2022). https://doi.org/10.1007/s11655-020-3285-2 ...
Inhibition of the PI3K-Akt-mTORC1-S6K1 axis impairs downregulation of Gfi-1, a negative regulator of Th17 differentiation. Furthermore, the authors show that S6K2, a nuclear counterpart of S6K1, is induced by the PI3K-Akt-mTORC1 axis, binds RORγ, and carries RORγ into the nucleus. ...
3.5. PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy In vitro, we first detected the protein expressions of microtubule-associated protein light chain 3 in the HT22 cells (LC3) following Aβ25-35 (40 μM) treatment for various times and following Aβ25-35 treatme...
5. VEGF作用4小时后,内皮细胞中mTOR和p70 S6K蛋白磷酸化水平明显增加,但PI3K/Akt的特异性抑制剂Wortmannin或LY294002可完全阻断VEGF的这一作用。 6. VEGF明显促进内皮细胞迁移(188.0%±5.5% vs.对照组, P 0.001);而VEGF+LY294002或者VEGF+Wortmannin组与对照组比较,内皮细胞的迁移无差别(89.3%±11.3%及83.7...
OncoTargets and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer This article was ...
et al. FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. Tumor Biol. 35, 10707–10714 (2014). https://doi.org/10.1007/s13277-014-2386-y Download citation Received09 June 2014 Accepted23 July 2014 Published30 July...
摘要: MLZD ameliorated glycolipid metabolism and inflammation, which may be attributed to the regulation of PI3K-Akt/mTOR-S6K1/AMPK-PGC-1 α pathways.关键词: Chinese medicine obesity type 2 diabetes mellitus glycolipid metabolism adipokines inflammation ...
Noradrenaline Enhances The Expression Of The Neuronal Monocarboxylate Transporter Mct2 By Translational Activation Via Stimulation Of PI3K/Akt And The MTOR/S6K Pathway 作者: Chenal, Julie;Pellerin, Luc;摘要: Monocarboxylate transporter 2 (MCT2) expression is up-regulated by noradrenaline (NA) in ...
Additionally, S100A4 overexpression increased the phosphorylation levels of Akt, mTOR and p70S6K. These effects of S100A4 were abolished by treatment with either the specific PI3K/Akt inhibitor LY294002, or the specific mTOR/p70S6K inhibitor rapamycin. Furthermore, overexpression of S100A4 resulted ...