王婉婷,许颖,邵命海.中药单体靶向PI3K/Akt/mTOR信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2023,57(10): 83-88. WANG W T,XU Y,SHAO M H.Research progress in monomers of traditional Chinese herbal medicine targetin...
Recent data suggests that the PI3K-AKT-mTOR signaling pathway plays an important role in cancer stem cell self-renewal and resistance to chemotherapy or radiotherapy, which is believed to be the root of treatment failure and cancer recurrence, as well as metastasis. 癌症中的PI3K-mTOR信号途径 ...
Akt activates multiple downstream targets, including the mTOR pathway. Akt in this patyway is flanked by two tumor suppressors, PTEN and TSC1/TSC2 heterodimer. Variousreceptor tyrosine kinases(RTKs), such ashuman epidermal growth factor receptor 2(HER2),epidermal growth factor receptor(EGFR),...
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is crucial for normal human physiology and also frequently dysregulated in several human cancers, including breast cancer (BC). A number of clinical trials targeting this pathway are already underway in...
2024年1月保定市第一中心医院耿红玉教授团队于《Int Immunopharmacol》(IF=5.6)杂志上发布了文章:Sivelestat ameliorates sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway,本研究旨在探讨西维来司他钠在脓毒症诱导心肌功能障碍(SIMD)中的作用机制。结果显示:西维来司他钠在体内...
pathway炎 症是一种机体应对外界感染 、组织损伤及其他细胞应激的
pathwaythatpromotescellularsurvivalandtherapeuticresistanceisthePI3K/Akt/mTORpathway (1, 2). It is activated by oncogenes such as ras or erbB2, receptor tyrosine kinases, G proteincoupled receptors, or inactivation of the tumor suppressor gene, PTEN, that normally negativelyregulates this pathway. ...
18、 pathway plays an important role in cancer stem cell self-renewal and resistance to chemotherapy or radiotherapy, which is believed to be the root of treatmentfailure and cancer recurrence, as well as metastasis.癌症中的PI3K-mTOR信号途径Figure 1 | Minding your Ps: the PtdIns(4,5)P2 PtdIn...
综上所述,作者的研究结果揭示了α-Cyperone对HeLa细胞生长的抑制作用是通过ROS介导的PI3K/Akt/mTOR信号通路触发的,并且与PD-L1表达的下降密切相关。 英文题目:α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway. 期刊杂志:European Journal...
1PI3K/Akt/mTOR Signaling Pathway and Its Role in Autophagy and TumorSHU Ting,WAN Fu-Sheng *(Department of Biochemistry and Molecular Biology,Basic Medical College of Nanchang University,Nanchang 330006,China)Abstract Autophagy is a self-digesting mechanism that characteristics of occurring double-...