Following many years of studying growth factor signaling pathways, it has been defined that this signaling pathway plays a crucial role in regulation of cell proliferation, survival, and differentiation. One of the crucial downstream effector of PI3K identified as the Akt kinase, also known as PKB...
Ching CB,Hansel DE.Expanding therapeutic targets in bladder cancer:the PI3K/Akt/m TOR pathway[J].Lab Invest,2010;90(10):1406-14.Ching CB, Hansel DE. Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest. 2010;90:1406 - 1414....
This review highlights the role of PI3K/AKT/mTOR signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation, and discusses how this signaling pathway affects development of the disease. We also summarize recent evidences of therapeutic approaches to treat OA by targeting ...
the PI3K/AKT pathway, which is further related to MDR, including the expression of apoptosis-related protein, ABC transport and glycogen synthase kinase-3 beta (GSK-3β), synergism with nuclear factor kappa beta (NF-κB) and mammalian target of rapamycin (mTOR), and the regulation of ...
Journal of Neuroscience Research 87:2297–2307 (2009) Amyloid-b Interrupts the PI3K-AktmTOR Signaling Pathway That Could Be Involved in Brain-Derived Neurotrophic Factor-Induced Arc Expression in Rat Cortical Neurons Tsan-Ju Chen,1* Dean-Chuan Wang,2 and Shun-Sheng Chen3 1 Department of ...
We further investigated the possible mechanism of Mito-Tempo on autophagy during glutamate-induced cytotoxicity through the PI3K/Akt/mTOR signaling pathway using Western blot analysis. The expression levels of p-PI3K, p-Akt, p-mTOR significantly decreased in the glutamate-treated cells compared with ...
Sun C-H, Chang Y-H & Pan C-C (2011) Histopathology58, 1054鈥 1063 Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladderAims: Phosphatidylinositol3-kinase (PI3K)/Akt/mammalian target of ...
Short interfering PI3K suppressed the PI3K/AKT/mTOR pathway to induce apoptosis and reduce autophagy of alveolar epithelial cells in an in vitro model of COPD. Activation of PI3K induced the PI3K/AKT/mTOR pathway to reduce apoptosis of alveolar epithelial cells in the in vitro model of COPD by...
IFNγ regulates sepsis-induced immunosuppression by promoting the Warburg effect through the PI3K/AKT/mTOR pathway The mechanism of the Warburg effect involves the activation of AKT through PI3K phosphorylation. Activated AKT then upregulates the expression of HIF-1α through mTOR. HIF-1α upregulates...
6b). To elucidate whether inhibiting the PI3K/Akt signaling pathway can reduce PDAC cell invasion and migration, transwell invasion, and migration assays were performed using LY294002-treated PANC-1 and MIA PaCa-2 cells with or without LAMB3 overexpression. Inhibition of the PI3K/Akt signaling ...