共转染1.0g Tau-V5和Pyk2 KD SHSY-5Y细胞组的P110β,P85α,p-AKT(Thr308),AKT,和GSK3β蛋白表达没有明显变化.p-P85α,P110α,p-AKT(Ser437)和p-GSK3β(Ser9)蛋白表达明显减少.结论Pyk2在雄性APP/PS1双转基因AD小鼠模型中高表达,且Pyk2通过PI3K/AKT/Gsk3b信号调控Tau蛋白PHF-1[Phospho-Tau(Ser396/...
目的:研究鳖甲煎丸对肝癌细胞Hep3B增殖和转移的影响,探讨其抗肝细胞癌的作用机制.方法:分别使用不同浓度的鳖甲煎丸药物血清培养Hep3B肝癌细胞,采用CCK8,细胞划痕实验观察肝癌细胞增殖和转移能力的改变;采用WesternBlot检测PI3K,p-AKT,GSK-3β,p-GSK-3β,E-cadherin,N-cadherin,Snail蛋白表达的变化;采用qPCR检测MMP...
Braz JC, Gill RM, Corbly AK, Jones BD, Jin N, Vlahos CJ, Wu Q, Shen W. Selective activation of PI3K␣/Akt/GSK-3 signalling and car- diac compensatory hypertrophy during recovery from heart failure. Eur J Heart Fail 11: 739 -748, 2009....
cisplatin-resistanceOVARIANcancerPI3K/AKT/GSK-3βpathwayObjective To investigate whether low-dose fractionated radiation(LDFRT) could enhance cisplatin sensitivity in drug-resistant human ovarian cancer cells SKOV3/DDP, and to further explore the underlying mechanism.Methods SKOV3/DDP ovarian cancer cells...
(GSK3β) signaling pathway, a pivotal player in renal fibrosis, was down-regulated following TRPC6 deletion.#These results suggest that the ablation of TRPC6 may mitigate renal fibrosis by inhibiting the apoptosis and inflammation of PTECs through down-regulation of the PI3K/AKT/GSK3β pathway....
T. Nizamutdinova et al., "PTEN differentially regulates expressions of ICAM-1 and VCAM- 1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells," Atherosclerosis, vol. 213, no. 1, pp. 115-121, 2010....
Similarly, the phyto-β-SERM diet downregulated Gsk3b and upregulated neuroprotective genes in AD brain. Conclusions Results from this study indicate that in vivo activation of ERβ promotes PI3K/AKT-mediated but not RAS/MAPK-mediated insulin signaling in female brain. Such an effect could ...
6 methy1coumarin promotes me1anogenesis through the pka creb mapk akt pi3k and gsk3b b ca10in signa1ing pathways 来自 28 喜欢 0 阅读量: 14 作者:T Kim,JK Kang,CG Hyun 摘要: We investigated the effects of four coumarin derivatives, namely, 6-methylcoumarin, 7-methylcoumarin, 4-hydroxy-6...
6 methy1coumarin promotes me1anogenesis through the pka creb mapk akt pi3k and gsk3b b ca10in signa1ing pathwaysWe investigated the effects of four coumarin derivatives, namely, 6-methylcoumarin, 7-methylcoumarin, 4-hydroxy-6-methylcoumarin, and 4-hydroxy-7-methylcoumarin, which have similar ...