PI3K inhibitors are finally coming of age Bart Vanhaesebroeck, Matthew W. D. Perry, Jennifer R. Brown, Fabrice André & Klaus Okkenhaug Nature Reviews Drug Discovery volume 20, pages 741–769 (2021)Cite this article 30k Accesses 148 Altmetric Metrics details An Author Correction to this ...
Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has been hampered by issues such as poor drug tolerance and drug resistance, several PI3K inhibitors have now received regulatory approval...
PI3K inhibitors are finally coming of age Article 14 June 2021 The emerging role of PI3K inhibitors for solid tumour treatment and beyond Article 13 March 2023 References Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). Article CAS Pu...
[4]Fruman D A, Chiu H, Hopkins B D, et al. The PI3K pathway in human disease. Cell, 2017, 170(4): 605-635. [5]Vanhaesebroeck B, Perry M W D, Brown J R, et al. PI3K inhibitors are finally coming ...
1.Vanhaesebroeck B, Perry MWD, Brown JR, André F, Okkenhaug K. PI3K inhibitors are finally coming of age [published correction appears in Nat Rev Drug Discov. 2021 Sep 1;:]. Nat Rev Drug Discov. 2021;20(10):741...
1. Vanhaesebroeck B, et al. PI3K inhibitors are finally coming of age. Nat Rev Drug Discov. 2021 Oct;20(10)741-769. 2. Bilanges B, et al. PI3K isoforms in cell signalling and vesicle trafficking. Nat Rev Mol Cell Biol. 2019 Sep;20(9)515-534. ...
1.Vanhaesebroeck B, Perry MWD, Brown JR, André F, Okkenhaug K. PI3K inhibitors are finally coming of age [published correction appears in Nat Rev Drug Discov. 2021 Sep 1;:]. Nat Rev Drug Discov. 2021;20(10):741-769. doi:10.1038/s41573-021-00209-1. ...
3. Vanhaesebroeck, B., Perry, M. W. D., Brown, J. R., André, F. & Okkenhaug, K. PI3K inhibitors are finally coming of age. Nat. Rev. Drug Discov.20, 741–769 (2021).4. Ali, K. et al. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance...
[9]Vanhaesebroeck, B., Perry, M., Brown, J. R., André, F., & Okkenhaug, K. (2021). PI3K inhibitors are finally coming of age. Nature reviews. Drug discovery, 20(10), 741–769.[10] Mishra, R., Patel, H., Alanazi, S., Kilroy, M. K., & Garrett, J. T. (2021). ...
1. Vanhaesebroeck, B., Perry, M. W. D., Brown, J. R., Andre, F. & Okkenhaug, K. PI3K inhibitors are finally coming of age. Nat. Rev. Drug Discov. 20, 741–769 (2021).2. Fruman, D. A. et al. The PI3K pathway in human disease. Cell 170, 605–635 (2017).想了解...