3.Pi3K inhibitors as new cancer therapeutics: implications for clinicaltrial design. 4.Novel Molecular-targeted Antitumor Drugs-PI3K Inhibitor. 2018年8月全球批准新药概况 乳腺癌最有潜力靶点——CDK4/6抑制剂盘点与解析 药渡APP全面升级啦!一览全球获批新药,中国临...
Expert Opin Investig Drugs. 2017 Nov;26 (11):1267-1279. doi:10.1080/13543784.2017.1384815. 5.Idelalisib: First-in-Class PI3KDelta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma. Clin Cancer Res. 2015 Apr1;21(7):1537-42. doi:...
[6]. Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines[J].Brigette B.Y.Ma,Vivian W.Y.Lui,Connie W.C.Hui,Cecilia P.Y.Lau,Chi-Hang Wong,Edwin P.Hui,Margaret H.Ng,S.W.Tsao,Yan Li,Anthony T.C.Chan.Investigational New Drugs.2013(3)[7]. Corrig...
(KRAS G12C) had selective activity in cell lines harboring the corresponding target. Lastly, combination effects were observed from vertical inhibition of the PI3K/AKT/mTOR pathway with a PI3K inhibitor in combination with either the mTORC1/2 inhibitor sapanisertib or an AKT inhibitor, ipataser...
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg. Med. Chem. Lett. 23, 3741–3748 (2013). Together with Fritsch et al. (2014), this work shows how the optimization of hydrogen bonding interactions at the ...
PI3K抑制剂在乳腺癌治疗中的应用现状
Case presentation: We describe a 74-year-old woman who developed severe uncontrolled hyperglycemia after commencing alpelisib, a new oral PI3K inhibitor indicated for a metastatic breast cancer, despite taking oral anti-diabetic drugs, metformin and vildagliptin, combined with intravenous insulin infusion...
Next, to understand the mechanistic basis of PI3Kδi-induced toxicity and anti-tumour immune responses, we tested the effect of a PI3Kδ inhibitor in a mouse solid tumour model. We inoculated wild-type C57BL/6 mice with B16F10-OVA melanoma cells and treated them with the PI3Kδi PI-3065...
withPI一3KinhibitorLY294002and Paclitaxelininvivoovariancancermodel Candidatefor master:Wang xiaonan Supervisor:ProfoXinxiaoyan Department of Obstetrics&GynecologyXiJingHospital,FourthMiIitary Medical UniversityXi’an710032,China Abstraet Malignant tumorisasort ofdiseasethat drastically threatenshuman healthand li...
1.1.2 主要试剂 澳洲源胎牛血清、RPMI 1640(Gibco);BSA(Amresco);小鼠脾脏淋巴细胞分离液、TRIzol Reagent、Recombinant Mouse IL-36 β/IL-1F8、RIPA Buffer、Protease/Phosphatase inhibitor cocktail、Anti-rabbit IgG, HRP-linked ...