triple-negative breast cancerPI3KAKTPTENtargeted therapypredictive biomarkersTriple-negative breast cancer (TNBC) is characterised by poor outcomes and a historical lack of targeted therapies. Dysregulation of signalling through the phosphoinositide 3 (PI3)-kinase and AKT signalling pathway is one of the ...
SANDPIPER: Phase III study of the PI3-kinase (PI3K) inhibitor taselisib (GDC-0032) plus fulvestrant in patients (pts) with oestrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic breast cancer (BC) enriched for pts with PIK3CA-mutant tumours...
et al. The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis. Cancer Lett 338, 229–238, doi: 10.1016/j.canlet.2013.03.032 (2013). 30. Serova, M. et al. Benchmarking effects...
PI3 Kinase p110 Alpha Monoclonal Antibody for WB, IHC, IF/ICC, FC (Intra), ELISACat No. 67071-1-Ig CloneNo. 1F6A7 引用文献(116) 宿主/亚型 Mouse / IgG2b 种属反应性 human, mouse, rat, pig, rabbit and More (3) 应用 WB, IHC, IF/ICC, FC (Intra), ELISA and More (3) ...
(20 ng ml−1) and the p110α specific PI3-kinase inhibitor BYL-719 (500 nM). Assay was carried out as described fora. ANOVA statistical analysis was performed with starved cells used as reference for each condition (NS, not significant; ***P<0.001). Box and whisker plot was ...
klJ822Mu 小鼠B-细胞κ-轻肽基因增强子抑制因子激酶β(IκBKβ)ELISA试剂盒现货供应 ELISA Kit for Inhibitor Of Kappa- Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb) klA549Mu 小鼠角蛋白9(KRT9)ELISA试剂盒现货供应 ELISA Kit for Keratin 9 (KRT9) klB817Mu 小鼠多功能蛋白聚糖(VS)...
► Role of PI3-kinase/Akt/mTOR signaling in diffuse large B cell lymphoma (DLBCL). ► Mcl-1 downregulation facilitates cell death in DLBCL of the ABC and GCB subtype. ► Dual inhibition of PI3K and mTOR induces cell death mainly in GCB DLBCL. ► Mcl-1 expression is decreased only...
Optimal dosages to be administered may be readily determined by those skilled in the art, and will vary with the particular PI3 kinase inhibitor in use, the strength of the preparation, the mode of administration, and the advancement of the disease condition. Additional factors depending on the...
the compound of Example 56 or 70; a JAK3 kinase inhibitor, e.g. N-benzyl-3,4-dihydroxy-benzylidene-yanoacetamide α-cyano-(3,4-dihydroxy)-]N-benzylcinnamamide (Tyrphostin AG 490), prodigiosin 25-C (PNU156804), [4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline] (WHI-P131), [...
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