Interestingly, adrenal function in advanced age leads to changes in the diurnal pattern of cortisol, which shifts earlier in the day and produces higher evening cortisol levels.68,104 Clinically, these sleep disturbances are manifested by a relatively earlier bedtime and awakening compared with younger...
Boyd DHA (1975) Failure of resulution in pneumonia. Br J Dis Chest 69:259–266 PubMed CAS Google Scholar Brain R (1963) The neurological complications of neoplasms. Lancet 1:179–184 Google Scholar Brandfonbrener M, Landowne M, Shock NW (1955) Changes in cardiac output with age. Circ...
Long-term variability in physiological measures may cause many negative effects, such as systemic inflammation, muscle damage, impaired blood glucose regulation, and stress on the kidneys [13,14,15,16], and these adverse changes in physiological functions are recognized risk factors for CVD [17,18...
Age-related changes in emotional processing are complex, with a bias toward positive information. However, the impact of aging on emotional responses in positive everyday situations remains unclear. Virtual Reality (VR) has emerged as a promising tool for investigating emotional processing, offering a...
(tertiary age changes) have been studied with regard to the effect of those changes on the pharmacodynamics of drug action. In general, age-associated pharmacodynamic changes, i.e. changes in the type, intensity and duration of drug action, have been associated with changes in receptor function...
Galhardo MS, Caldini EG, Battlehner CN, Toledo OM. 2012. Age-dependent physiological changes in the histoarchitecture of the articular cartilage of the rabbit mandibular condyle: a morphological and morphometric study. Cells Tissues Organs. 195(4):340-352....
The weight loss typically experienced in this population is due to failure to eat rather than changes in metabolic state. The introduction of an aquarium to the group dining room led to increased nutritional intake and weight gain. The aquarium held resident’s attention and encouraged them to ...
Metabolic changes in both cardiomyocytes and non-cardiomyocytes contribute to pathological remodelling of the heart. The new paradigm for studying metabolic remodelling in heart failure faces challenges but also offers opportunities to develop novel therapies to treat heart failure. This is a preview of ...
Japanese-style bathing (JSB), which involves soaking in hot water up to the shoulders in deep bathtubs for a long time in the evening to night, is unique. Many experimental and epidemiological studies and surveys have shown that JSB improve sleep quality
Overall, our observations indicate that partial reprogramming protocols can be designed to be safe and effective in preventing age-related physiological changes. We further conclude that longer-term partial reprogramming regimens are more effective in delaying aging phenotypes than short-term reprogramming....