In this article we will outline some of the physiological changes, particularly cardiorespiratory, associated with the ageing process that will be of relevance to anaesthesia.SimonL.MaguireandBenjaminM.J.SlaterSDOSAnaesthesia & Intensive Care Medicine
Ageing is a physiological process that affects virtually all systems of the human body. Age-associated changes in the oral cavity reflect changes in the composition of its microbial inhabitants, which can be compatible with health or form dysbiotic communities that favor the establishment of disease....
D. et al. Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55–79 years. Aging Cell 17, e12735 (2018). Article PubMed Central CAS Google Scholar Chakravarty, E. F., Hubert, H. B., Lingala, V. B. & Fries, J. F. ...
This study identifies ovarian vascular decline as a key physiological driver of fertility loss in middle-aged female mice and demonstrates that restoring vascular function with Salidroside might be a promising approach to improve fertility in aged females. ...
Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing1,2,3,4. However, the molecular mechanisms leading to the loss of transcriptional fidelity are so far elusive, as are ways of preventing it. Here we...
Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or eve
This outcome was unsurprising given that the physiological effects of ageing are associated with diminishing strength and mobility gains in response to exercise [4]. As such, people in the oldest age groups often need a greater intensity, frequency and duration of exercise in order to make ...
Age-related muscle wasting is due to disrupted muscle protein turnover, a process mediated in part by the ubiquitin proteasome pathway (UPP). Additionally, older subjects have been observed to have an attenuated anabolic response, at both the molecular and physiological levels, following a single-...
Physiological changes in the human can be roughly divided into two stages, development and ageing. The developmental and ageing forms of face can reflect the differences between these two stages37. The age range from 4 to 40 years chosen in this study could basically cover the development and ...
Adult stem cells of muscle tissue, quiescent under normal physiological conditions and activated on injury. Pioneer factor Bookmarking transcription factor that can directly bind and recruit other chromatin remodellers to condensed chromatin, allowing initiation of new molecular programmes and cell fate tra...