In subject area:Biochemistry, Genetics and Molecular Biology DYRK1A is considered as a dual-specificity protein kinase that catalyzes the phosphorylation of both serine and threonine residues of the substrates after getting self-activated through auto-phosphorylation of a tyrosine residue (Tyr-321) pres...
Protein phosphorylation is a unique mode of posttranslational protein modification which enables a rapid activation or deactivation of a protein, via the addition of a phosphate group (PO43−) to a protein. From:Progress in Molecular Biology and Translational Science,2012 ...
- 《Journal of Cell Biology》 被引量: 220发表: 2007年 Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in ...
Binding of the mammalian transcription factor E2F to the adenovirus E2a early promoter is modulated through interaction with the viral E4-6/7 protein. E4-6... S Obert,RJ O'Connor,S Schmid,... - 《Molecular & Cellular Biology》 被引量: 267发表: 1994年 Repression of RAD51 gene expressio...
4a, bottom; lane 2 vs 3), a pharmacologic CK2 inhibitor, expression of MZF1 returned to the level of the control (Fig. 4a, top; lane 3 vs 4). To confirm the correlation between the expression level of MZF1 and CK2 activity, we used the non-phosphorylatable MZF1 S27A mutant that ...
The in vitro demethylase assay showed that Jhd2-S321A, S340A reduced H3K4me3 to a lower level than WT Jhd2 (Fig. 3c, lane 3 vs lane 2), indicating that Jhd2-S321A, S340A has a higher demethylase activity than WT Jhd2. We also purified unphosphorylated Jhd2 from tpk2Δ mutant (...
Oxidative phosphorylation (OXPHOS) is a multi-enzyme process located in the inner mitochondrial membrane (IMM) by which electrons from reduced metabolites are transferred to the ultimate electron acceptor oxygen, which is reduced to water. From:Journal of Molecular Biology,2018 ...
Scholey - 《Journal of Molecular Biology》 被引量: 87发表: 1983年 Phosphorylation and actin activation of brain myosin. A method is described for obtaining brain myosin that shows significant actin activation, after phosphorylation with chicken gizzard myosin light chain kinase. Myosin with this ...
To better understand the determinants of HIF-1 binding a... X Xia,AL Kung - 《Genome Biology》 被引量: 167发表: 2009年 Dynamic and stable histone H3 methylation patterns at the Arabidopsis FLC and AP1 loci H3K27me3 modifications co-exist at 5′-end nucleosomes of transcriptionally active...
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