This method eliminates the matrix effect and amplifies the signal obtained by using silicon dioxide nanoparticles (SiO2 NPs) biofunctionalized with the 伪pTau181 antibody. Our results indicate a substantial increase in the serum concentration of pTau in threonine-181 during hibernation, which disappears...
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 ...
Cerebrospinal fluid (CSF) phospho‐tau181 (p‐tau181) is an established biomarker of tangle pathology in Alzheimer's disease (AD), but does not detect aberrant tau phosphorylation in other tauopathies. Recently, tau phosphorylation at threonine7 (p‐tau217) was suggested to be a superior ...
A previous study demonstrated that cerebrospinal fluid (CSF) phosphorylated tau 217 (pTau217), compared to phosphorylated tau 181 (pTau181), correlated more strongly with Tau PET and was better able to distinguish between AD and non〢D neurodegenerative diseases. The aim of this study was to ...
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Plasma phosphorylated tau 181 (P-tau181) and 217 (P-tau217) are indicators of both amyloid and tau pathology in clinical settings, but their performance in heterogeneous community-based populations is unclear. We examined P-tau181 and P-tau217 (n = 1,329, aged 30–98 years), in...
目的 观察老年急性脑梗死(ACI)患者血清磷酸化tau蛋白181(P-tau-181)和激肽释放酶6(KLK6)水平变化,并探讨其与患者发病后睡眠障碍的关系。方法 选择2020年5月至2022年5月海安市人民医院收治的158例老年ACI患者作为观察对象,根据美国国立卫生研究院卒中量表(NIHSS)评分,将其分为轻度组(40例)、中度组(81例)和重度...
Associations of Baseline Plasma Phosphorylated Tau at Threonine 181 (P-Tau181) and Neurofilament Light Chain (NfL) With Decreasing Glucose Metabolism and Increasing Atrophy View LargeDownload Regression lines displayed in graphs were computed by setting covariates in the linear model to average group ...
Furthermore, significant changes in plasma EV biomarkers of P-tau181, Aβ 1–42, and cathepsin were observed in EVs in AD23. EVs have also been shown to carry proteins related to the key pathologies in AD, such as P-tau27and Aβ28. EVs may facilitate the spread of these proteins bet...
Increased levels of CSF tau and phosphorylated tau (p-tau 181) correlate with memory deficits in mild cognitive impairment - Alzheimer's & Dementia: The Journal of the Alzheimer's Associationdoi:10.1016/j.jalz.2009.04.1185Kanemaru, Kazutomi...