Approximately 90% of alpha-synuclein (α-Synuclein) deposited in Lewy bodies is phosphorylated at serine 129 suggesting that the accumulation of phosphorylated α-Synuclein is critical in the pathogenesis of Parkinson's disease. However,in vivoexperiments addressing the role of phosphorylated α-...
alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 4:160-164. doi:10.1038/ncb841Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M.S., Shen, J., Takio, K., and Iwatsubo, T. (2002). α-Synuclein is phosphorylated in ...
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Exp. Neurol. 210, 409-420.Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, et al. Relationship of phosphorylated alpha-synuclein and ...
The decline in the brain mitochondrial function of aged mice was accompanied by early-onset impairment of motor function, including the slowness of movement and reduced exploratory and voluntary motor activities, and the increased accumulation of the synaptic protein α-synuclein phosphorylated at Ser129...
alpha-Synuclein is phosphorylated in synucleinopathy lesions. Highly selective enrichment of phosphorylated peptides using titanium dioxide. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
中文名称: Synuclein, alpha, phosphorylated (S129) (SNCA, Alpha-Synuclein, PD1, NACP, PARK1, PARK4) (MaxLight 490) 中文同义词: 英文名称: Synuclein, alpha, phosphorylated (S129) (SNCA, Alpha-Synuclein, PD1, NACP, PARK1, PARK4) (MaxLight 490) 英文同义词: Synuclein, alpha, phosphorylate...
Aβ, amyloid-β; MMSE, mini-mental state examination; pSer129 α-syn, alpha-synuclein phosphorylated at serine 129; α-syn, α-synuclein. Full size image Aβ treatment induced phosphorylation at Ser129 in α-syn-overexpressing SHSY-5Y cells Exposure of cells to aggregated Aβ1-42 (10 μM...
The specific binding ratio on I-123-ioflupane imaging was decreased in the PD/DLB group, but it was not correlated with the CSF alpha-synuclein level. These results indicate that (1) the CSF alpha-synuclein level is a useful biomarker of PD/DLB; (2) the CSF levels of tau, p-tau, ...
Phosphorylated alpha-synucleinTi4+@TiP nanoparticlesImmunosensorA highly sensitive and specific surface plasmon resonance (SPR) method using one anti-alpha-synuclein antibody (anti-αS) and titanium phosphate nanoparticles (Ti@TiP) was developed for quantitative evaluation of phosphorylated αS level which...
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders. Expert Rev Mol Diagn 2012; 12: 115-7.Phosphorylated alpha-synuclein as a potential biomarker for Parkinson’s disease and related disorders. Penelope Foulds,David M. A. Mann,David Allsop. EXPERT ...