中文名称:磷酸化致癌基因C-Myc抗体 英文名称:Anti-phospho C-Myc(Thr58/pSer62)别名:Myc(Phospho-Thr58); AU016757; Avian myelocytomatosis viral oncogene homolog; bHLHe39; c My包装号:G320 产地:中国大陆/进口产品 商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology供应商:田源试剂 TR、新试剂...
SynonymsMRTL; MYCC; c-Myc; bHLHe39 CategoryCancer Biology; Epigenetics Backgroundc-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene ...
Here, we show a therapeutic effect by inducing nucleotide imbalance and apoptosis in triple negative breast cancer cells (TNBC), by treating with cytosolic thymidylate 5'-phosphohydrolase (CT). We show that a sustained consumption of dTMP by CT could induce dNTP imbalance, leading to apoptosis ...
It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol(2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, ...
This strategy has been successfully employed for a number of pro- tein kinase inhibitors designed to target human kinases in the treat- ment of cancer40 including the clinically approved Bcr–Abl inhibitor Imatinib (Gleevec)41. That a similar approach to drug design may be effective in the ...
You might find these chapters and articles relevant to this topic. NAMPT: A critical driver and therapeutic target for cancer Massimiliano Gasparrini, Valentina Audrito, in The International Journal of Biochemistry & Cell Biology, 2022 Abstract Nicotinamide phosphoribosyltransferase (NAMPT) possesses...
Functional proteomics identifies miR- NAs to target a p27/Myc/phospho-Rb signature in breast and ovarian can- cer. Oncogene. 2015;2:469.Seviour EG, Sehgal V, Lu Y et al: Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. ...
Intramolecular Contact Switch Is Crucial for Brd4-Regulated c-Myc and c-Fos Gene Transcription To define whether the intramolecular contact switch is a general mechanism for Brd4-regulated transcription, we further analyzed Brd4 recruitment to c-Myc and c-Fos genes not containing obvious p53-binding...
Cancer Molecular Therapy and Department of Biochemistry College of Medicine, Dong-A University Busan 602-714, Korea 2Department of Physiology College of Medicine, The Catholic University of Korea Seoul 137-701, Korea and 3Department of Life Science Pohang University of Science and Technology Pohang ...
Cancer Centrosome mRNA Phosphorylation RNA-binding Protein Introduction The cyclin-dependent kinase (Cdk)2 family is implicated in cell cycle progression, cell differentiation, and migration. The Cdk family contains two types of members: first a the common one, which must bind to cyclin proteins to...