Hepatic apolipoprotein B (apoB) lipoprotein production is metabolically regulated via the phosphoinositide 3-kinase cascade; however, the role of the key negative regulator of this pathway, the tumor suppressor phosphatase with tensin homology (PTEN), is unknown. Here, we demonstrate that hepatic ...
1.Phosphatase and tensin homologue deleted on chromosome 10, pten.人第10号染色体缺失的磷酸酶及张力蛋白同源的基因
3) Phosphatase and tesion homologue deleted on chromosome ten 第10号染色体同源缺失性磷酸酶-张力蛋白基因4) phosphatase and tensin homology deleted onchromosome10 第10染色体同源丢失性磷酸酶张力蛋白基因5) phosphatase and tensin homologue deleted on chromosome ten 第10染色体缺失与张力蛋白同源的磷酸酶...
1. CpG island methylation status of phosphatase and tension homology deleted on chromosome ten gene and its expression in bladder transitional cell carcinoma 磷酸酶基因CpG岛甲基化状态及其在膀胱移行细胞癌中的表达更多例句>> 2) Phosphatase and tensin homology deletedon chromosome ten(PTEN protein) ...
It was demonstrated that higher expression of miR‑198 was observed in patients with SLE, and was correlated with disease activity. Bioinformatics prediction and luciferase assays were used to demonstrate that miR‑198 could directly bind to the phosphatase and tensin homology deleted on chromosome...
3.4 PTENP1 (phosphatase and tensin homolog pseudogene 1) PTENP1 is a PTEN pseudogene (tumor suppressor gene), located on chromosome 9p13.3. PTENP1 (RNA or gene) is ~ 1 kb shorter than PTEN, but has ~ 95% homology between them at the 5′ region and 50% homology toward the 3′ end ...
Evidence That SHIP-1 Contributes to Phosphatidylinositol 3,4,5-Trisphosphate Metabolism in T Lymphocytes and Can Regulate Novel Phosphoinositide 3-Kinase E... The leukemic T cell line Jurkat is deficient in protein expression of the lipid phosphatases Src homology 2 domain containing inositol ...
The 3-phosphatase, phosphate and tensin homologue deleted on chromosome 10 (PTEN) dephosphorylates the third position of PI(3,4,5)P3 to generate PI(4,5)P2 (refs 25,26), whereas inositol polyphosphate 5-phosphatases (5-phosphatases), such as Src homology 2-containing inositol 5-phosphatase ...
PTEN (phosphatase and tensin homolog deleted on chromosome 10) has indeed a negative role in CXCR4-mediated chemotaxis of primary B cells [46]. Moreover, PTEN-null Jurkat cells exhibit potent chemotactic responses to CXCL12 [47]. Chemotaxis is also inhibited in CXCL12-stimulated Jurkat cells ...
Akt activation is tightly controlled by counteraction of phosphatases, and tensin homologue deleted on chromosome 10 (PTEN) (10), protein phosphatase 2A (PP2A) (11, 12, 13, 14, 15, 16), and pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) (17) was reported to ...