Terminal elimination half-life: 2–3 hours following oral or IV administration.Observed effective half-life: Approximately 5 minutes following IV infusion.Special PopulationsClinical data regarding effects of renal or hepatic impairment on phenylephrine pharmacokinetics are limited....
(FDA MedWatch definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * requires intervention to prevent permanent impairment or damage * First published case report A 29-year-old man developed a typeIV reaction manifesting as drug ...
In contraction experiments, endothelin-1 (10 pM to 0.1 µM), phenylephrine (1 nM to 100 µM), or AVP (10 pM to 1 µM) were added in cumulative half-log10increments, allowing time for the response to plateau between additions. Contractions in response to each drug concentration are ...