duration of action. Binding of phenylephrine to the α1receptor leads to a number of pharmacologic effects. On the arterial vasculature, α1-receptor activation by phenylephrine leads to increases in arterial pressure, systemic vascular resistance (SVR), and ventricular afterload. On the venous side...
To further elucidate the mechanisms of the positive inotropic effect of PE, action potential configuration and 45 Ca 2+ fluxes were monitored in the rat left atrium. The increase in F c by PE was associated with an increase in action potential duration (APD) and a reduction in resting ...
The amine, at all three concentrations, increased the duration of the action potential and effective refractory period in electrically driven preparations. When applied at the higher concentration, phenylephrine induced a positive chronotropic effect in spontaneously beating preparations; this effect was ...
Her mother then remembered that her daughter had received the same preparation at the time of the first hypertensive episode [ dosage and duration of treatment to reaction onset not stated ]. Author Comment "According to Naranjo's algorithm, the causal relationship between medication and hypertension...
Has been added to solutions of some local anesthetics to decrease rate of vascular absorption and prolong duration of spinal anesthesia† [off-label].Decreases risk of systemic toxicity due to the local anesthetic.Not as effective as epinephrine in prolonging local anesthesia but may be preferred ...
Normal eyes will not demonstrate mydriasis in response to this low concentration of phenylephrine. Third order Horner’s syndrome of greater than two weeks duration is associated with receptor up regulation and therefore a response to 0.25% phenylephrine is noted. In this way, the diagnosis of ...
Normal eyes will not demonstrate mydriasis in response to this low concentration of phenylephrine. Third order Horner’s syndrome of greater than two weeks duration is associated with receptor up regulation and therefore a response to 0.25% phenylephrine is noted. In this way, the diagnosis of ...
As the duration of cold storage was extended, the difference between the values of membrane and potassium equilibrium potentials gradually decreased (Fig. 1). There are several possible explanations which might explain this: (1) an increase in potassium permeability,Q() a decrease in sodium ...
In canine ventricle, alpha-adrenergic agonists prolong action potential duration (APD) without any effect on the action potential notch, suggesting that, in this species, the effect on repolarization might be independent of inhibition of I(to). The present study investigated the action of the ...
(Anaesthesia. 2019;74:850鈥 855) Phenylephrine is the preferred vasopressor for treating spinal-induced hypotension during cesarean delivery due to its rapid onset, short duration of action, and lack of adverse effects on fetal acid-base status. However, norepinephrine is often used in critical...