Phenobarbital-induced prolongation of half-life and alteration of distribution of a phenothiazine drug metabolite in the ratEnergy TechnologyGeothermal Energy ConversionHeat TransferWater ResourcesDry HeatElectric Power SuppliesEnergy DistributionEnthalpy
4. Doxycycline:Phenobarbital has been shown to shorten the half- life ofdoxycyclinefor as long as 2 weeks after barbiturate therapy is discontinued. This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize theantibiotic. If phenobarbital and doxycycline are administer...
Regardless of the compartment model displayed by these compounds, the biological half-life of each compound was significantly shorter in the phenobarbital-treated rats than in the control rats. This effect was attributed to the possible induction effect of phenobarbital on the renal tubular secretion ...
Phenobarbital and primidone therapy may also lead to altered pharmacokinetics in concomitantly administered AEDs, whose metabolism may be increased, and lead to lowered plasma levels and/ or a shorter halflife: carbamazepine, ethosuximide, lamotrigine, oxcarbazepine, phenytoin, valproate, tiagabine, topir...
Phenobarbital has the lowest lipid solubility, lowest plasma binding, lowest brain protein binding, the longest delay in onset activity, and the longest duration of action. The plasma half-life for phenobarbital in adults ranges between 53 and 118 hours with a mean of 79 hours. The plasma half...
according to response in steps of 2 mg at intervals of not less than 2 weeks, to a maximum of 12mg daily. maintenance doses are usually in the range of 4 to 8 mg daily. patients who are also taking drugs that shorten the half-life of perampanel should be titrated at intervals of no...
Phenytoin and phenobarbitone are first choice antiepileptic medications for many because of its easy accessibility, affordability and simple dosing due to its long mean half life1. Despite the fact that Phenytoin (P) and Phenobarbital (Pb) are often prescribed concomitantly, few cases of severe comb...
The rise in plasma phenobarbital was paralleled by lengthening of phenobarbital elimination half-life while the decrease of plasma phenobarbital clearance paralleled the decrease in phenobarbital elimination rate constant. These findings suggest that inhibition of phenobarbital metabolism by valproate is the ...
How long does phenobarbital last? Tablets or elixirs begin to act in about 60 minutes,2 and their duration lasts for10 to 12 hours,3 depending on the dosage and individual metabolism. The plasma half-life of phenobarbital in adults is an average of about 79 hours and 110 hours in...
Pharmacokinetics of phenobarbital was examined in 6 mature horses after 12 mg of phenobarbital/kg of body weight was infused over 20 minutes. Biexponential decrease in serum phenobarbital concentrations was observed with a distribution-phase half-life of 0.101 +/- 0.086 hour (mean +/- SD) and a...