Management and Mitigation of Human Drug–drug Interaction Risks in the Drug Discovery and Development Phasesdoi:10.1002/9781118783344.ch16cytochrome P450 (CYP) enzymedrug discoverydrug transportersdrug-drug interaction (DDI) riskstransporter-mediated DDIHeidi J. Einolf...
Although the major part of the basal HeLa ADP-ribosylome remained unchanged upon all tested H2O2 concentrations, some selected peptides change the extent of ADP-ribosylation depending on the degree of the applied oxidative stress. Low oxidative stress (i.e. 4 μm and 16 μm H2O2) caused a ...
The overconsumption of highly caloric and palatable foods has caused a surge in obesity rates in the past half century, thereby posing a healthcare challenge due to the array of comorbidities linked to heightened body fat accrual. Developing treatments t
such as fungicides and herbicides, and not part of the ToxCast dataset. These compounds were not launched on the market but failed for different reasons during the development. In the YAS assay, human androgen receptor is expressed in yeast cells. Upon binding ...
Using a hypothesis-free approach to gene discovery involving expression arrays constitutes a novel approach to understanding this condition. For our studies, we employed a previously characterized model of CRPS involving limb fracture and cast immobilization in rodents [20]. Our results showed that ...
a)PhaseI b)PhaseII c)PhaseIII d)PhaseIV Answers TheabovetrialisbestdescribedasaphaseIIItrial(answerc). Thedevelopmentofadrugfollowsawellestablishedand lengthyprocess.Itmaytakebetween10and15yearstodevelop anewdrugfromdiscoverytowhenitisavailablefortreating patients.Drugsaretestedinhumansonlyaftertheyhave under...
(1996) Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction. Am J Respir Cell Mol Biol 15: 771-780. doi: 10.1165/ajrcmb.15.6.8969272 [61] Kishimoto T (2010) IL-6: From its discovery to clinical ...
A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic sy
Enantioselective chromatography in drug discovery. Drug Dis. Today 2005, 10, 571–577. [CrossRef] 3. Francotte, E. Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers. J. Chromatogr. A 2001, 906, 379–397. [CrossRef] Molecules 2016, 21, 1051 10...
H OH metabolites OH Article Modelling of Hydrophilic Interaction Liquid Chromatography Stationary Phases Using Chemometric Approaches Meritxell Navarro-Reig ID , Elena Ortiz-Villanueva, Romà Tauler and Joaquim Jaumot * ID Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 ...