Netzer et al, HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery, Current Opinion in Drug Discovery and Development, Current Drugs, vol. 6, No. 4, Jul. 1, 2003, pp. 462-469....
In the following series of studies, it was shown that varying levels of drug resistance can affect the rate of dormancy-dependent recrudescence20. The persister parasites exhibit an altered pattern of development21, expressing several genes related to metabolism22 and cell cycle regulation23. More...
The ICO programs are especially valuable in today’s challenging biopharma job market, according to Paul McGonigle, co-director of the ICO division, director of thedrug discovery and development programand professor of pharmacology. “This is the sort of thing that helps distinguish yo...
gossypii were successfully obtained through a previously established induction platform, and the morphological characteristics, developmental dynamics, and temporal gene expression were examined. Subsequently, signaling pathways potentially involved in regulating the growth, development, and reproduction of sexual ...
Uterine leiomyoma (uterine fibroids) pipeline market report provides comprehensive information on the therapeutics under development for Uterine Leiomyoma (Uterine Fibroids), complete with analysis by stage of development, drug target, mechanism of actio
The development of simple and effective treatment regimens that minimize negative side effects can make a huge difference. We are excited to see this progress for patients with EGFR-mutated lung cancer, where there is still significant...
The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages. The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration det...
not as high as with cigarette smoking. Thus, while someone who smokes one pack of cigarettes per day has a risk for the development of lung cancer that is 25 times higher than a nonsmoker, pipe, and cigarsmokershave a risk of lung cancer that is about five times that of a nonsmoker....
1a and Methods). Immunofluorescence assays (IFA) confirmed its nuclear location at various stages suggesting a basal level of PfAP2-P protein throughout the IDC (Extended Data Fig. 1d). Fig. 1: PfAP2-P is essential for parasite growth and development. a, Schematic of strategy showing ...
not as high as with cigarette smoking. Thus, while someone who smokes one pack of cigarettes per day has a risk for the development of lung cancer that is 25 times higher than a nonsmoker, pipe, and cigarsmokershave a risk of lung cancer that is about five times that of a nonsmoker....