In vitro studies of BrdU-dependent sister chromatid differential staining typically employ two cycles of BrdU incorporation. Experiments are described which determined the actual fraction of both S-phases that the rat embryonic fibroblasts (Rat-1) cells had to traverse in order to show distinctive ...
When all chromosomes achieve a bipolar attachment to the spindle, the APC is activated, sister chromatids separate, and the cell exits mitosis. The cell cycle is not over until cell division is completed to produce two daughter cells in G1. Recently, an additional checkpoint pathway has been ...
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What is the second phase of mitosis? What is the term for the phase of mitosis where chromosomes line up across the center of the cell? The first stage of mitosis: a. prophase b. metaphase c. anaphase d. telophase A nucleus is built around chromatids which hav...
During which phase of mitosis do sister chromatids separate to opposite poles of the cell? During which phase of mitosis do the chromatids become chromosomes? In which phase of mitosis do chromosomes line up at the middle of the cell? Which phase of meiosis is most like mito...
cohesion between sister chromatids is destroyed and anaphase sets in [1,19]. Normally in eukaryotes, chromosomes get bi-oriented in metaphase. In the budding yeast, since SPBs duplicate and separate in S-phase forming a short mitotic spindle and the centromeres replicate early, bipolar attachment...
Moreover, condensin II loop extrusion activity has been implicated in interphase chromatin folding and spatial partitioning37,38,39 as well as in the resolution of newly replicated sister chromatids to prevent entanglements prior to mitosis40. However, while the functions of condensins outside of ...
DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ). To repair DSB
stability outside of mitosis. We propose that condensin II targets BLM to sites where its substrates are most likely to occur during DNA replication, thereby increasing the efficiency by which BLM encounters and repairs its substrates in newly replicated sister chromatids prior to entry into ...
When all chromosomes achieve a bipolar attachment to the spindle, the APC is activated, sister chromatids separate, and the cell exits mitosis. The cell cycle is not over until cell division is completed to produce two daughter cells in G1. Recently, an additional checkpoint pathway has been ...