b.An instance of such a proceeding:the trial of Socrates. 2. a.The act or process of testing, trying, or putting to the proof:a trial of one's faith. b.An instance of such testing, especially as part of a series of tests or experiments:a clinical trial of a drug. ...
Methods: We describe the protocol of a multi-centre, open-label, phase II clinical trial of metformin in up to 49 evaluable patients with intermediate-risk NMIBC with the aim to determine the overall response to administration of oral metformin for 3 months on a marker tumour deliberately left...
19 The benefits of triplet chemotherapy with gemcitabine-cisplatin plus nab-paclitaxel are underscored by the findings of a phase 2 clinical trial (protocol No. PrE0204), in which 74 patients with newly diagnosed cholangiocarcinoma received doublet therapy with gemcitabine plus nab-paclitaxel.20 That...
Incannex have designed the follow-up Phase 2B clinical trial, PsiGAD2, with the assistance of Clerkenwell Health, a UK based contract research organisation specialising in psychiatry and CNS treatments. This trial will be conducted ...
Hydroxyquinone, for example, found to be effective in a small clinical trial [9] failed to show efficacy in a larger trial [10]. Likewise, the trial on Lopinavir-Ritonavir in adults with COVID-19 concluded that “future trials in patients with severe illness may help to confirm or exclude...
This open-label, single-arm, phase 2 trial evaluated the efficacy and safety of neoadjuvant sintilimab combined with anlotinib and chemotherapy, followed by adjuvant sintilimab, for resectable NSCLC. Forty-five patients received anlotinib (10 mg, QD,
The study protocol was approved by the independent ethics committee of the Medical Faculty at the University of Heidelberg. The trial was carried out by adhering to local legal and regulatory requirements. The study complies with the Declaration of Helsinki 2004, the principles of Good clinical ...
To address a potential risk of epistaxis identified during the study in period 1, the following exclusion criteria were added (protocol amendment no. 3): Patients on concomitant antiplatelet therapy (for example, clopidogrel), anti-coagulants (for example, warfarin, heparin, factor Xa inhibitor or...
2). The area under the curve (AUC) was 0.987 for the training set and 0.722 for test set 1; the addition of individual clinical parameters did not significantly improve the predictive power (Fig. 3, Extended Data Fig. 6 and Supplementary Table 6). The final multiparametric GAM–LASSO (...
The 235kg patient was recruited with a significant neuropathic wound, an infection that affects one or more nerves, on the left side of his left foot. The patient was on systemic therapy and was required to stop treatment to meet...