Arbuck SG. Workshop on phase I study design:Arbuck, S. G. (1996). Workshop on phase I study design. Ninth NCI/EORTC New Drug Development Symposium, Amsterdam, March 12, 1996. Ann. Oncol. 7, 567-573.Arbuck SG. Workshop on phase I study design. Ninth NCI/EORTC new drug ...
FOLFIRINOX-R study design: a phase I/II trial of FOLFIRINOX plus regorafenib as first line therapy in patients with unresectable RAS-mutated metastatic colorectal cancer Antoine Adenis, Thibault Mazard, Julien Fraisse, Patrick Chalbos, Brice Pastor, Ludovic Evesque, Francois Ghiringhelli...
On day 29 the patients received a pre-dose infusion of HH1 (50 mg, cold CD37 antibody) followed by the radioimmunoconjugate 177Lu-DOTA-HH1administered as a 10 minute iv bolus. A 3 x 3 dose escalation design was used with 10 MBq/kg as the starting level. Patients were assessed for...
We design an Asian phase I trial using the Bayesian continual reassessment method. First we analyze toxicity data from a Caucasian trial to derive the ... K Takeda,S Morita - 《Therapeutic Innovation & Regulatory Science》 被引量: 1发表: 2014年 ...
concentration whilst introducing small amounts of Fe, but also compensates for the strength loss via oxygen solute strengthening. Our alloys achieve spatially uniform microstructures and mechanical properties which are superior to those of Ti−6Al−4V. This study may help to guide the design of ...
The limitations of this study include the single-center design of the phase Ia stage of the study which may reduce the generalizability of the findings, but was implemented to enable optimal safety oversight of the early stages of the trial. In addition, this study only included Chinese patients...
A Microsoft Certified Systems Engineer is trained and certified on a range of Microsoft systems products, including components of the Microsoft BackOffice™. MCSEs understand the interactions and benefits of Windows NT Directory Services, replication issues, and architectural design for multiple network ...
Trial Design This study comprises a dose escalation (step 1) to determine the Dose-Limiting Toxicities, Maximum Tolerated Dose (MTD), and Recommended phase II Dose (RP2Ds) of BI 765063 monotherapy and with BI 754091, and dose-confirmation expansion cohorts (step 2). In Step 1, ascending ...
This parametric study was done for a temperature ratio range of 1.5 to 2.0 and for hot-end temperatures of 875 K and 1075 K. A conceptual design of a 1080 K FPSE with a linear alternator producing 25 kWe output was completed. This was a single-cylinder engine designed for a 62,000 ...
TSP-1 reprograms the TME via binding to CD36 and CD47 to induce tumor and endothelial cell apoptosis as well as immune modulation in the TME. Methods Study VT1021-01 (ClinicalTrials.gov ID NCT03364400) used a modified 3 + 3 design. The primary objective was to determine the ...