Machine learning or a causal inference paradigm separately has been adopted for many pharmacovigilance studies [11,12,13,14,15]. The integration of machine learning into a causal inference paradigm was also studied, although mostly theoretically [16,17,18,19,20]. However, the relationship between ...
The levels of semantic annotation in different corpora determine the types of information that can be recognised by TM tools. Named Entities (NEs), i.e., semantically categorised words/phrases, such as drugs and disorders, form the basis for a number of more complex types of annotation. Sever...
J Pharm Res. 2012;5(2):864–868. 3. World Health Organization. The Safety of Medicines in Public Health Programmes: Pharmacovigilance, an Essential Tool. Available from: http://www.who.int/medicines/areas/quality_safety/safety_efficacy/ Pharmacovigilance_B.pdf. Accessed April 28, 2017. 4. ...
Versions Notes Abstract (1) Background: Antimicrobial resistance (AMR) requires urgent multidisciplinary solutions, and pharmacovigilance has the potential to strengthen current antimicrobial stewardship strategies. This study aimed to characterize AMR-relevant adverse drug reaction (ADR) reports submitted to ...
Review Reports Versions Notes Abstract Using the WHO pharmacovigilance (PV) indicators as a framework, this study aimed to explore the structures, processes, and outcomes of three Arab countries’ (Jordan, Oman, and Kuwait) PV systems to inform recommendations for countries with nascent PV systems....
Versions Notes Abstract The impressive advances in the knowledge of biomarkers and molecular targets has enabled significant progress in drug therapy for crucial diseases such as cancer. Specific areas of pharmacology have contributed to these therapeutic outcomes—mainly targeted therapy, immunomodulatory the...
Versions Notes Abstract Introduction: Adverse drug reactions are a significant problem in modern society, stemming from the increase in prescribed medications, over-the-counter drugs, and overall polypharmacy. Glomerular disorders are one of the frequently reported renal conditions associated with medication...
Versions Notes Abstract Drug-induced liver injury (DILI) with nintedanib has emerged as an adverse event of special interest in premarketing clinical trials. We characterized DILI with nintedanib in the real world and explored the underlying pharmacological basis. First, we assessed serious hepatic ev...
Versions Notes Abstract Criteria have been developed to identify potentially inappropriate medications that can enhance adverse reactions, highly prevalent in older patient’s therapy. This study aimed to identify potentially inappropriate medications within the adverse drug reactions reported in the Portuguese...
Versions Notes Abstract With the rapid development of the pharmaceutical industry and constant growth of drug usage, ecopharmacovigilance (EPV) has emerged as a way of coping with and minimizing the effects that drugs have on the environment. EPV concerns and describes unwanted effects that the use...