Define Pharmacovigilance. Pharmacovigilance synonyms, Pharmacovigilance pronunciation, Pharmacovigilance translation, English dictionary definition of Pharmacovigilance. abbr. 1. photovoltaic 2. polyvinyl American Heritage® Dictionary of the English L
Later, when it appeared that, with higher drug concentrations, the risk for serious adverse effects (e.g., anticholinergic effects of tricyclic antidepressants [1] ) increased dramatically, the interest for a definition of toxic levels prompted authors to publish case studies. Interestingly, TDM ...
This is where IND-enabling studies play a pivotal role, providing the requisite data on pharmacology, pharmacokinetics, and toxicology to understand the drug’s behavior in the body and its potential effects on various biological systems. IND-enabling studies are a series of preclinical assessments t...
- 《European Journal of Clinical Pharmacology》 被引量: 1107发表: 1998年 Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Purpose: Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced ...
The lack of consensual definition, with multiple criteria possible: clinical symptoms, EKG modification, cardiac enzyme elevation, decrease in cardiac function assessed by either echocardiography or cMRI and exclusion of differential diagnoses; all for which details were not mentioned in VigiBase®22. ...
Defining 'signal' and its subtypes in pharmacovigilance based on a systematic review of previous definitions. Having surveyed the etymology and previous definitions of the pharmacovigilanceterm 'signal', we propose a definition that embraces all the surveyed ideas,... DM Hauben,JK Aronson - 《Drug ...
As many herbal products on the market have not been thoroughly tested for their pharmacology and toxicology, pharmacovigilance has paramount importance in detecting unwanted reactions. In addition there is an ongoing problem with unexpected toxicity of herbal products due to quality issues, including use...
in July 2021, Chemotargets launched CLARITY PV, a new web-based platform for translational safety and pharmacovigilance purposes. CLARITY PV platform contains highly-curated structured and integrated data covering the entire safety lifetime of a drug, from safety pharmacology, through preclinical toxicolo...
By application of the anaphylaxis case definition, 2 cases belonging to group A and 139 to group B were excluded after individual review. Out of 193 reports meeting the case definition, 8 (4.1%) were reported in children and adolescents up to 18 years of age. The most reported responsible ...
Euro- pean Journal of Pharmacology 52: 423-427. Borg, J. J., Tanti, A., Kouvelas, D., Lungu, C., Prozynski, M., Serracino-Inglott, A., Aislait- ner, G. (2015). European Union Pharmacovigilance Capabilities: Potential for the New Legislation. Therapeutic Advances in Drug Safety ...