The potential targets of XHP for prostate cancer were gathered from the Gene ontology and KEGG pathway. Furthermore, cell proliferation assays were verified by PC3 and LNCaP cells. The efficacy and potential mechanism tests were confirmed by the PCa PC3 cells and mice subcutane...
Potential target proteins and their network analyses. (a) Venn diagram of candidate drug targets for prostate cancer. Group A: Targets from studies of prostate cancer; Group B: Targets from studies of cancers except prostate cancer; Group C: Targets from studies of chronic prostatitis; Group D:...
A quarter of the 490 proteins of interest in prostate cancer (Prot_PCa) are detectable in LNCaP cells using current mass spectrometry equipment. b For detectable proteins in LNCaP cell lysate SRM assays were developed. Examples of ion chromatograms show four co-eluting transitions with base line...
Applications of the principles of cancer pharmacology are embedded in the continuum from early drug discovery through preclinical development, and then bridging to the preapproval stages of clinical development. During the development phases for a cancer drug, it is essential to monitor the relati...
select article The efficacy and safety of PI3K and AKT inhibitors for patients with cancer: A systematic review and network meta-analysis Research articleAbstract only The efficacy and safety of PI3K and AKT inhibitors for patients with cancer: A systematic review and network meta-analysis Yingshi ...
One of the first drugs that was used clinically in modernmedicinefor the treatment ofcancerwas thealkylating agentmechlorethamine, a nitrogen mustard that in the 1940s was found to be effective in treatinglymphomas. In 1956 the antimetabolitemethotrexatebecame the first drug to cure a solidtumour...
Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer 来自 掌桥科研 喜欢 0 阅读量: 48 作者:J Xie,J Wu,S Yang,H Zhou 摘要: Background. Aloe vera has long been considered an...
Anticate drugs are effective means to treat diseases such as prostate hyperplasia, prostate cancer, acne, and hair loss. Among them, non-steroids, such as3-Fangji-5,5-Trifer Byeyl-oligoma compounds occupy an important position. Such as nilutamide, can be used for the treatment of prostate...
Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex Prostate cancer is the first most common malignancy in men worldwide; this cancer is characterized by a marked propensity for invasion and spreading ...
This phenomenon appears to hold true for the Bmi-1 pathway. Expression profiling on metastatic versus primary prostate tumors from human patients and the murine TRAMP transgenic model revealed substantial elevation of Bmi-1 and its associated molecular signature of 11 genes in metastatic cancer (44)...