To enhance renal excretion, consider furosemide 20–40 mg IV push to maintain urine output >100 mL/m2/h or 2 mL/kg/h. Diuretic use is contraindicated if the patient has evidence of acute obstructive uropathy or hypovolemia. Potassium must also be closely monitored due to furosemide’s ability...
However, the potent diuresis induced by agents such as furosemide results in loss of sodium and other essential electrolytes, which may exacerbate hyponatremia. Fluid restriction is only moderately effective and often difficult to implement in the hospital setting. Agents such as demeclocycline and ...