Schapel GJ , Beran RG , Doecke CJ , et al . (1988) Pharmacokinetics of sodium valproate in epileptic patients: prediction of maintenance dosage by single-dose study . European Journal of Clinical Pharmacology , 17 , 71 - 77 .Schapel, G.; Beran, R.; Doeche, C.; O’Reilly, W.; ...
17. OBJECTIVE: To study thepharmacokineticsand pharmacodynamics of verapamil in patients with hypertension. 目的:研究维拉·帕米在高血压患者的药代动力学及药效学。 youdao 18. Objective: to compared thepharmacokineticsof sodium valproate suppository with sodium valproate tablets. ...
17. OBJECTIVE: To study the pharmacokinetics and pharmacodynamics of verapamil in patients with hypertension. 目的:研究维拉·帕米在高血压患者的药代动力学及药效学。 youdao 18. Objective: to compared the pharmacokinetics of sodium valproate suppository with sodium valproate tablets. 目的:比较丙戊酸钠栓剂...
Myrj 51 as a suppository excipient: Influence on pharmaceutical availability and bioavailability of sodium valproate Sodium valproateSuppositorySurfactantThe nonionic, water-soluble surfactant myrj 51, which is known to be well tolerated physiologically, was tested in a ... MV Margarit,IC Rodríguez,A ...
Sodium valproate is a widely prescribed broad-spectrum antiepileptic drug. It shows high inter-individual variability in pharmacokinetics and pharmacodynamics and has a narrow therapeutic range. We evaluated the effects of polymorphic uridine diphosphate glucuronosyltransferase (UGT)1A6 (541A>G, 552A>C...
Pharmacokinetics and bioavailability of sodium valproate The pharmacokinetics of the antiepileptic drug, sodium valproate (VPA), was investigated in 6 healthy volunteers after a single intravenous dose of 400 mg,... U Klotz,KH Antonin - 《Clinical Pharmacology & Therapeutics》 被引量: 532发表: 1977...
Tiagabine metabolism is also enhanced by concurrent medication with enzyme-inducing anticonvulsants, resulting in a need to use dosages larger than those required in monotherapy or valproic acid (sodium valproate)-treated patients. Additional investigational antiepileptic agents included in this article are...
Pharmacokinetics of sodium valproate in epileptic patients after an intravenous bolus administration. Mehta, A.C.; Calvert, R.T.; Rigby, J. et al.: Journal of Clinical and Hospital Pharmacy 5: 329 (1980). Google Scholar A prospective randomised trial on the effect of monitoring plasma antico...
The effects of salicylic acid on the pharmacokinetics of valproic acid were investigated in bile-exteriorized rats. A 50 mg/kg bolus dose of sodium valproate was injected iv to Long Evans rats with and without (control) prior treatment by constant infusion of salicylate to keep it at steady ...
Also studied were the influence of age on the serum NZP level and the drug interaction of phenobarbital (PB) or sodium valproate (VPA). Serum half-lives of NZP were also calculated in 9 epileptic children under long-term treatment. A significant correlation (r=0.683, p<O.Ol, n=60) was...