Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGDreceptor: wherein Y is bicyclic ring; Ris optionally substituted heteroaryl; Ris hydrogen, etc.; Ris —CH—CH—CH—CH—CH═CH—COOR, —CH—CH—CH—CH—X—CH—COOR, —CH—CH═...
The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. DP1 is a G protein-coupled receptor (GPCR). Its action is primarily mediated by G-S proteins that stimulate adenylate cyclase ensuing i
PGD2 / TXA2 both receptor antagonist pharmaceutical composition Examples of the compound having both receptor antagonism of prostaglandin D and thromboxane A the formula (I): (In the formula, an alkylene which may have an unsaturated bond A; m is 1 or 0;; X; 1 p is 0 or hydroxy and -...
人杀菌肽B(CecB)ELISA试剂盒 Human cecropin B,CecB ELISA KitELISA. 96T/48T大鼠坏死因子可溶性受体Ⅱ(TNFsR-Ⅱ)ELISA试剂盒Rat Tumor necrosis factor soluble receptor Ⅱ,TNFsR-Ⅱ ELISA KitELISA. 96T/48T鸡17羟皮质类固醇(17-OHCS)ELISA试剂盒Hydroxycorticosteroids,17-OHCS ELISA Kit ELISA. 96T/48T人血...
Selective prostaglandins EP_1 receptor antagonist inhibits afferent activity of Cunit of saphenous nerve in diabetic rats; 选择性前列腺素EP_1受体阻断剂抑制糖尿病大鼠隐神经中C单位的传入活动 2. Change in intestinal free radical and prostaglandin metabolism in the aged rats with Pneumococcus pneumonia;...
小鼠白介素23受体检测试剂盒IL23RInterleukin 23 Receptor0.258ng/mL0.1 小鼠雷帕霉素靶蛋白C1检测试剂盒mTORC1mammalian target of rapamyein C13.125100pg/mL0.1 小鼠3-吲哚丙酸检测试剂盒3-IPA3-IPA1.548ng/ml0.1 小鼠连环蛋白β1检测试剂盒β-cateninBeta Catenin0.516ng/mL0.1 ...
receptorEosinophilsThe first total synthesis of 15R-PGD2 3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE2. 15R-PGD2, a potential DP2 receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory ...
SDF-1α receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-). Thus, PGD2 deficiency results in food antigen-induced mast cell hyperplasia. 展开 DOI: 10.1038/ncomms8514 被引量: 9 ...
Objective To explore PGD2 biological characteristics in L-929 mice lung fibroblasts cell by Laropiprant is a specific inhibitor of PGD2 receptor regulation... J Liu,D Liu,Z Liu,... - 《Chongqing Medicine》 被引量: 0发表: 2014年 TGF-beta1 attenuates mediator release and de novo Kit expre...
人白介素2受体(IL-2R)免疫组化试剂盒Human Interleukin-2 receptor,IL-2R ELISA kitELISA. 96T/48T 人皮肤T细胞虏获趋化因子(CTACK/CCL27)免疫组化试剂盒Human cutaneous T cell-attracting chemokine,CTACK ELISA KitELISA. 96T/48T 人胸肾表达趋化因子(BRAK/CXCL14)免疫组化试剂盒Human Breast and kidney ...