The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttranslational modification (PTM) which regulates protein stability, localization, activation...
and the excessive proliferation and migration of pulmonary artery smooth muscle cell is the main cause of pulmonary vascular remodeling.Platelet-derived growth factor(PDGF-BB)is a powerful mitogenic factor which involved in cell proliferation and migration.Currently, plenty of studies have found that PD...
provided country-level data on LGBTI-inclusive school policies, which were then connected to individual-level data. Assessing each policy's inclusiveness involved the consideration of protected grounds, including variations in sexual characteristics, gender identity or expression, and sexual orientation. Th...
Arrondeau J, Huillard O, Tlemsani C, Cessot A, Boudou-Rou- quette P, Blanchet B, Thomas-Schoemann A, Vidal M, Tigaud JM, Durand JP et聽al (2015) Investigational therapies up to Phase II which target PDGF receptors: potential anti-cancer therapeu- tics. Expert Opin Investig Drugs 24...
To explore the underlying mechanism by which endothelial PDGFR-β regulates angiogenesis, we subjected bone morrow endothelial cells (BMECs) treated with PDGF-BB (300 ng·mL−1) to immunoprecipitation (IP) with an antibody against PDGFR-β followed by liquid chromatography with tandem mass spect...
of PDGF receptor signaling, by overexpression(超表达) or mutational(突变的) events, may drive tumor(肿瘤) cell growth. In addition, pericytes(周皮细胞) of the vasculature(脉管系统) and fibroblasts(纤维原细胞) and myofibroblasts of the stroma(基质) of solid tumors express PDGF receptors, and PD...
Signaling via PDGF receptors is carefully controlled and modulated. In the early phase of signaling different mechanisms assure that the signal rapidly reaches sufficient strength. For instance, in PDGF stimulated cells reactive oxygen species are produced in a PI3-kinase-dependent pathway, which inhibit...
(Ad-GFP) used as a control vector. To investigate role of PDGFRβ upon PDGF/BMP2 treatment we evaluated PDGF downstream signaling in sorted cells in which PDGFRβ was deleted by Ad-Cre (PDGFRβ−cells) and cells transduced with Ad-GFP and sorted as PDGFRβ+cells (Supplementary Fig.4a)...
(Figure1). In addition, the PDGF receptors bind other adaptors,e.g.Shc, Nck, Crk and GAB, which mediate interactions with a plethora of different downstream signaling molecules. The activation of these signaling pathways leads to cell proliferation and survival, as well as to actin ...
Thus, it is important to use more directed studies to identify which PKC isoform(s) is responsible for initiating the signaling response. With the correlative evidence for involvement of p120 S/T phosphorylation in disease states of decreased adhesion triggered by inflammation, and with the known ...